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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of L-Carnitine

L-carnitine powder

$4.28

g

* price without discount in nearest pharmacy. Price may vary.

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L-Carnitine volume of distribution

The steady state volume of distribution (Vss) of an intravenously administered dose, above endogenous baseline levels, was calculated to be 29.0 +/- 7.1L. However this value is predicted to be an underestimate of the true Vss.

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What is L-Carnitine

Constituent of striated muscle and liver. It is used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.

L-Carnitine mechanism of action

Levocarnitine can be synthesised within the body from the amino acids lysine or methionine. Vitamin C (ascorbic acid) is essential to the synthesis of carnitine. Levocarnitine is a carrier molecule in the transport of long chain fatty acids across the inner mitochondrial membrane. It also exports acyl groups from subcellular organelles and from cells to urine before they accumulate to toxic concentrations. Only the L isomer of carnitine (sometimes called vitamin BT) affects lipid metabolism. Levocarnitine is handled by several proteins in different pathways including carnitine transporters, carnitine translocases, carnitine acetyltransferases and carnitine palmitoyltransferases.

Dosage forms of L-Carnitine

FormRouteStrength
Injection, solutionintravenous1 g/5mL
Solutionintravenous200 mg
Liquidoral100 mg
Prescription Generics

false

International Brands

Carnitor

Synonyms

(-)-Carnitine (-)-L-Carnitine

Manufacturers

Sigma Tau Pharmaceuticals, Inc.

CAS number

541-15-1

UNII

0G389FZZ9M

State

solid

Affected organisms

Humans and other mammals

Indication of L-Carnitine

For treatment of primary systemic carnitine deficiency, a genetic impairment of normal biosynthesis or utilization of levocarnitine from dietary sources, or for the treatment of secondary carnitine deficiency resulting from an inborn error of metabolism such as glutaric aciduria II, methyl malonic aciduria, propionic acidemia, and medium chain fatty acylCoA dehydrogenase deficiency. Used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias. Parenteral levocarnitine is indicated for the prevention and treatment of carnitine deficiency in patients with end-stage renal disease.

Toxicity of L-Carnitine

LD sub50 /sub 8g/kg (mouse, oral). Adverse effects include hypertension, fever, tachycardia and seizures.

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