Save up -80% on Labetalol

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Labetalol

Normodyne 200 mg tablet

$1.0

tablet

* price without discount in nearest pharmacy. Price may vary.

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Labetalol volume of distribution

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What is Labetalol

Blocker of both alpha- and beta-adrenergic receptors that is used as an antihypertensive.

Labetalol mechanism of action

Labetalol HCl combines both selective, competitive, alpha-1-adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance. In man, the ratios of alpha- to beta- blockade have been estimated to be approximately 1:3 and 1:7 following oral and intravenous (IV) administration, respectively. The principal physiologic action of labetalol is to competitively block adrenergic stimulation of -receptors within the myocardium (1-receptors) and within bronchial and vascular smooth muscle (2-receptors), and 1-receptors within vascular smooth muscle. This causes a decrease in systemic arterial blood pressure and systemic vascular resistance without a substantial reduction in resting heart rate, cardiac output, or stroke volume, apparently because of its combined – and -adrenergic blocking activity.

Dosage forms of Labetalol

DrugDosageQuantityPrice
Trandate100mg100 Tablet$64.00
Trandate200mg100 Tablet$89.00
Trandate400mg112 Tablet$110.00
Labetalol400mg112 Tablet$92.50
Prescription Generics

true

International Brands

Apo-labetalol Tablets

Synonyms

3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol 5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide

Manufacturers

Apotex Inc

CAS number

36894-69-6

UNII

R5H8897N95

State

solid

Affected organisms

Humans and other mammals

Indication of Labetalol

For the management of hypertension (alone or in combination with other classes of antihypertensive agents), as well as chronic stable angina pectoris and sympathetic overactivity syndrome associated with severe tetanus. Labetalol is used parenterally for immediate reduction in blood pressure in severe hypertension or in hypertensive crises when considered an emergency, for the control of blood pressure in patients with pheochromocytoma and pregnant women with preeclampsia, and to produce controlled hypotension during anesthesia to reduce bleeding resulting from surgical procedures.

Toxicity of Labetalol

LD sub50 /sub = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue

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