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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Trandate

$16.2460 tablets/200 mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Labetalol coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Labetalol every time. What are you waiting for? Claim your prescription drug card now!

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Labetalol volume of distribution

Labetalol systemic clearance also decreased (23.2 5.3 to 17.7 3.7 ml/min/kg; p <0.05), but the volume of distribution was unchanged. Labetalol caused significant -blockade for 8 hours after the last oral dose, but Cimetidine did not alter pharmacologic response.

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What is Labetalol

Blocker of both alpha- and beta-adrenergic receptors that is used as an antihypertensive.

Labetalol mechanism of action

Labetalol HCl combines both selective, competitive, alpha-1-adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance. In man, the ratios of alpha- to beta- blockade have been estimated to be approximately 1:3 and 1:7 following oral and intravenous (IV) administration, respectively. The principal physiologic action of labetalol is to competitively block adrenergic stimulation of -receptors within the myocardium (1-receptors) and within bronchial and vascular smooth muscle (2-receptors), and 1-receptors within vascular smooth muscle. This causes a decrease in systemic arterial blood pressure and systemic vascular resistance without a substantial reduction in resting heart rate, cardiac output, or stroke volume, apparently because of its combined – and -adrenergic blocking activity.

Dosage forms of Labetalol

Trandate100mg100 Tablet$64.00
Trandate200mg100 Tablet$89.00
Trandate400mg112 Tablet$110.00
Labetalol400mg112 Tablet$92.50

Prescription Generics


International Brands

Apo-labetalol Tablets


3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol 5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide


Apotex Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Labetalol

For the management of hypertension (alone or in combination with other classes of antihypertensive agents), as well as chronic stable angina pectoris and sympathetic overactivity syndrome associated with severe tetanus. Labetalol is used parenterally for immediate reduction in blood pressure in severe hypertension or in hypertensive crises when considered an emergency, for the control of blood pressure in patients with pheochromocytoma and pregnant women with preeclampsia, and to produce controlled hypotension during anesthesia to reduce bleeding resulting from surgical procedures.

Toxicity of Labetalol

LD sub50 /sub = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue

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What is a Trandate?

Trandate tablets are adrenergic receptor blocking agents that have both blocking effects of selective alpha1-adrenergic and non-selective beta-adrenergic receptors in one substance.

Trandate tablets contain 100, 200 or 300 mg of labetalol HCl and are taken orally. The tablets contain inactive ingredients cornstarch, FD (only 100 and 300 mg tablets), hydroxypropyl methylcellulose, lactose, magnesium stearate, pregelatinized corn starch, sodium benzoate (only 200 mg tablet), talc (100 mg tablet) and titanium dioxide.