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Price of Lactulose
Kristalose 10 gm packet
* price without discount in nearest pharmacy. Price may vary.
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Lactulose volume of distribution
What is Lactulose
A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887)
Lactulose mechanism of action
Lactulose is a synthetic sugar used in the treatment of constipation and liver disease. It consists of the monosaccharides fructose and galactose. In the colon, lactulose is broken down primarily to lactic acid, and also to small amounts of formic and acetic acids, by the action of via evolved-beta galactosidase from colonic bacteria, which results in an increase in osmotic pressure and slight acidification of the colonic contents. This in turn causes an increase in stool water content and softens the stool. In treating heptic diseases (hepatic encephalopathy) it is thought that lactulose draws out ammonia from the body in the same way that it draws out water into the colon.
Dosage forms of Lactulose
|Syrup||miscellaneous; oral||667 mg|
|Syrup||oral; rectal||10 g|
Humans and other mammals
Indication of Lactulose
For the treatment of constipation and hepatic encephalopathy.
Toxicity of Lactulose
LD sub50 /sub=18.2 g/kg (oral, rat). Side effects include diarrhea and resultant dehydration.
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