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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Lamotrigine

Apo-Lamotrigine 150 mg Tablet

$1.31

tablet

* price without discount in nearest pharmacy. Price may vary.

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Lamotrigine volume of distribution

* 0.9 to 1.3 L/kg

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What is Lamotrigine

Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants, lamotrigine has relatively few side-effects and does not require blood monitoring. The exact way lamotrigine works is unknown. (Wikipedia)

Lamotrigine mechanism of action

One proposed mechanism of action of Lamotrigine, the relevance of which remains to be established in humans, involves an effect on sodium channels. iin vitro /i pharmacological studies suggest that lamotrigine inhibits voltage-sensitive sodium channels and/or calcium channels, thereby stabilizing neuronal membranes and consequently modulating presynaptic transmitter release of excitatory amino acids (e.g., glutamate and aspartate). Studies on lamotrigine show binding to sodium channels similar to local anesthetics.

Dosage forms of Lamotrigine

DrugDosageQuantityPrice
Lamictal25mg100 Tablet$77.00
Lamictal100mg56 Tablet$134.00
Lamictal150mg60 Tablet$1,070.00
Lamictal DC2mg30 Dispersible-Chewable Tablet$35.00
Lamictal DC50mg90 Dispersible-Chewable Tablet$119.93
Lamictal DC200mg90 Dispersible-Chewable Tablet$380.00
Lamotrigine50mg112 Tablet$65.00
Lamotrigine50mg112 Tablet$65.00
Lamotrigine150mg90 Tablet$83.00
Lamotrigine200mg56 Tablet$66.00
Lamotrigine Xr100mg100 Extended Release Tablet$87.00
Prescription Generics

true

International Brands

Apo-lamotrigine

Synonyms

3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine Lamictal

Manufacturers

Apotex Inc

CAS number

84057-84-1

UNII

U3H27498KS

State

solid

Affected organisms

Humans and other mammals

Indication of Lamotrigine

For the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome. Also for the maintenance treatment of bipolar I disorder and depression.

Toxicity of Lamotrigine

LD sub50 /sub=250 (mg/kg) (in rat, mice); LD sub50 /sub640 orally (mg/kg) (in rat, mice) (Sawyer). Symptoms of overdose include decreased level of consciousness, coma, delayed heartbeat, increased seizures, lack of coordination, and rolling eyeballs.

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