Save up -80% on Laronidase
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Aldurazyme
|$879.60||1 vial (5ml) 2.9mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Aldurazyme coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Laronidase every time. What are you waiting for? Claim your prescription drug card now!
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Laronidase volume of distribution
The mean volume of distribution (Vz) ranged from 0.24 to 0.6 L/kg. Mean plasma clearance (CL) ranged from 1.7 to 2.7 mL/min/kg, and the mean elimination half-life (t1/2) ranged from 1.5 to 3.6 hours. Most patients who received once-weekly infusions of ALDURAZYME developed antibodies to laronidase by week 12.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Laronidase
Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites.
Laronidase mechanism of action
Laronidase catalyses the hydrolysis of terminal alpha-L-iduronic acid residues of dermatan sulfate and heparin sulfate.
Dosage forms of Laronidase
|Concentrate for solution for infusion||Intravenous use||100 U/ml|
|Injection, solution, concentrate||intravenous||2.9 mg/5mL|
Humans and other mammals
Indication of Laronidase
For the treatment of mucopolysaccharidosis
Toxicity of Laronidase
Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, single dose toxicity, repeated dose toxicity and toxicity to reproduction. Genotoxic and carcinogenic potential are not expected.
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