Save up -80% on Laronidase

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Aldurazyme

$879.601 vial (5ml) 2.9mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Aldurazyme coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Laronidase every time. What are you waiting for? Claim your prescription drug card now!

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Laronidase volume of distribution

The mean volume of distribution (Vz) ranged from 0.24 to 0.6 L/kg. Mean plasma clearance (CL) ranged from 1.7 to 2.7 mL/min/kg, and the mean elimination half-life (t1/2) ranged from 1.5 to 3.6 hours. Most patients who received once-weekly infusions of ALDURAZYME developed antibodies to laronidase by week 12.

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2018 Statistics

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Total savings $4,735,080

What is Laronidase

Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites.

Laronidase mechanism of action

Laronidase catalyses the hydrolysis of terminal alpha-L-iduronic acid residues of dermatan sulfate and heparin sulfate.

Dosage forms of Laronidase

FormRouteStrength
Concentrate for solution for infusionIntravenous use100 U/ml
Injection, solution, concentrateintravenous2.9 mg/5mL
Solutionintravenous0.58 mg

Prescription Generics

false

International Brands

Aldurazyme

Synonyms

Alpha-L-iduronidase precursor

Manufacturers

Genzyme Corporation

CAS number

210589-09-6

UNII

WP58SVM6R4

State

liquid

Affected organisms

Humans and other mammals

Indication of Laronidase

For the treatment of mucopolysaccharidosis

Toxicity of Laronidase

Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, single dose toxicity, repeated dose toxicity and toxicity to reproduction. Genotoxic and carcinogenic potential are not expected.

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