Save up -80% on Lepirudin
Note: this is a drug discount program, not an insurance plan.
2018 Price of Lepirudin
Refludan 50 mg vial
* price without discount in nearest pharmacy. Price may vary.
We offer free Lepirudin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Lepirudin every time. What are you waiting for? Claim your prescription drug card now!
Lepirudin volume of distribution
* 12.2 L Healthy young subjects (n = 18, age 18-60 years) * 18.7 L Healthy elderly subjects (n = 10, age 65-80 years) * 18 L Renally impaired patients (n = 16, creatinine clearance below 80 mL/min) * 32.1 L HIT patients (n = 73)
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Lepirudin
Lepirudin is identical to natural hirudin except for substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63. It is produced via yeast cells. Bayer ceased the production of lepirudin (Refludan) effective May 31, 2012.
Lepirudin mechanism of action
Lepirudin forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen and initiate the clotting cascade. The inhibition of thrombin prevents the blood clotting cascade.
Dosage forms of Lepirudin
|Concentrate for solution for injection||Intravenous use||20 mg|
|Concentrate for solution for injection||Intravenous use||50 mg|
|Powder for solution||intravenous||50 mg|
Hirudin variant-1 Lepirudin recombinant
Humans and other mammals
Toxicity of Lepirudin
In case of overdose (eg, suggested by excessively high aPTT values) the risk of bleeding is increased.
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