Save up -80% on Lepirudin

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Lepirudin

Refludan 50 mg vial



* price without discount in nearest pharmacy. Price may vary.

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Lepirudin volume of distribution

* 12.2 L Healthy young subjects (n = 18, age 18-60 years) * 18.7 L Healthy elderly subjects (n = 10, age 65-80 years) * 18 L Renally impaired patients (n = 16, creatinine clearance below 80 mL/min) * 32.1 L HIT patients (n = 73)

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What is Lepirudin

Lepirudin is identical to natural hirudin except for substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63. It is produced via yeast cells. Bayer ceased the production of lepirudin (Refludan) effective May 31, 2012.

Lepirudin mechanism of action

Lepirudin forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen and initiate the clotting cascade. The inhibition of thrombin prevents the blood clotting cascade.

Dosage forms of Lepirudin

Concentrate for solution for injectionIntravenous use20 mg
Concentrate for solution for injectionIntravenous use50 mg
Powder for solutionintravenous50 mg
Prescription Generics


International Brands



Hirudin variant-1 Lepirudin recombinant


Bayer Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Lepirudin

For the treatment of heparin-induced thrombocytopenia

Toxicity of Lepirudin

In case of overdose (eg, suggested by excessively high aPTT values) the risk of bleeding is increased.

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