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Price of Leuprolide
Leuprolide 2wk 1 mg/0.2 ml kit
* price without discount in nearest pharmacy. Price may vary.
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Leuprolide volume of distribution
* 27 L intravenous bolus administration to healthy male volunteers
What is Leuprolide
Leuprolide belongs to the general class of drugs known as hormones or hormone antagonists. It is a synthetic 9 residue peptide analog of gonadotropin releasing hormone. Leuprolide is used to treat advanced prostate cancer. It is also used to treat uterine fibroids and endometriosis. Leuprolide is also under investigation for possible use in the treatment of mild to moderate Alzheimer’s disease.
Leuprolide mechanism of action
Leuprolide binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion.
Dosage forms of Leuprolide
|Powder for suspension, sustained-release||subcutaneous||28.2 mg|
|Powder for suspension, sustained-release||subcutaneous||35.8 mg|
Sanofi Aventis U.S. Llc
Humans and other mammals
Indication of Leuprolide
For treatment of prostate cancer, endometriosis, uterine fibroids and premature puberty
Toxicity of Leuprolide
In rats subcutaneous administration of 250 to 500 times the recommended human dose, expressed on a per body weight basis, resulted in dyspnea, decreased activity, and local irritation at the injection site. There is no evidence at present that there is a clinical counterpart of this phenomenon. In early clinical trials with leuprolide acetate doses as high as 20 mg/day for up to two years caused no adverse effects differing from those observed with the 1 mg/day dose.
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