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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Ergamisol

$7.5g
price without discount in nearest pharmacy. Price may vary.

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What is Levamisole

An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6). Levamisole was withdrawn from the US and Canadian markets in 2000 and 2003, respectively, due to the risk of serious side effects and the availability of more effective replacement medications. (Wikipedia)

Levamisole mechanism of action

The mechanism of action of levamisole as an antiparasitic agent appears to be tied to its agnositic activity towards the L-subtype nicotinic acetylcholine receptors in nematode muscles. This agonistic action reduces the capacity of the males to control their reproductive muscles and limits their ability to copulate. The mechanism of action of Levamisole as an anticancer drug in combination with fluorouracil is unknown. The effects of levamisole on the immune system are complex. The drug appears to restore depressed immune function rather than to stimulate response to above-normal levels. Levamisole can stimulate formation of antibodies to various antigens, enhance T-cell responses by stimulating T-cell activation and proliferation, potentiate monocyte and macrophage functions including phagocytosis and chemotaxis, and increase neutrophil mobility, adherence, and chemotaxis.

Dosage forms of Levamisole

FormRouteStrength
Tabletoral50 mg

Prescription Generics

false

International Brands

Ergamisol Tab 50mg

Synonyms

Levamisol Levamisolum

Manufacturers

Janssen Inc

CAS number

14769-73-4

UNII

2880D3468G

State

solid

Affected organisms

Humans and other mammals

Indication of Levamisole

For adjuvant treatment in combination with fluorouracil after surgical resection in patients with Dukes’ stage C colon cancer. Also used to treat malignant melanoma and head/neck cancer. Levamisole was originally used as an antihelminthic to treat worm infestations in both humans and animals.

Toxicity of Levamisole

LDsub50/sub = 40 mg/kg (Pigs, subcutaneous); LDsub50/sub = 180 mg/kg (rat, oral)

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