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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Roweepra

$13.0160 tablets/500 mg
Price with discount in nearest pharmacy. Price may vary.

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Levetiracetam volume of distribution

Levetiracetam is not bound to plasma proteins and has a volume of distribution of 0.5-0.7 L/kg. Plasma concentrations increase in proportion to dose over the clinically relevant dose range (500-5000 mg) and there is no evidence of accumulation during multiple administration.

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What is Levetiracetam

Levetiracetam is an anticonvulsant medication used to treat epilepsy. Levetiracetam may selectively prevent hypersynchronization of epileptiform burst firing and propagation of seizure activity. Levetiracetam binds to the synaptic vesicle protein SV2A, which is thought to be involved in the regulation of vesicle exocytosis. Although the molecular significance of levetiracetam binding to synaptic vesicle protein SV2A is not understood, levetiracetam and related analogs showed a rank order of affinity for SV2A which correlated with the potency of their antiseizure activity in audiogenic seizure-prone mice.

Levetiracetam mechanism of action

The precise mechanism(s) by which levetiracetam exerts its antiepileptic effect is unknown. The antiepileptic activity of levetiracetam was assessed in a number of animal models of epileptic seizures. Levetiracetam did not inhibit single seizures induced by maximal stimulation with electrical current or different chemoconvulsants and showed only minimal activity in submaximal stimulation and in threshold tests. Protection was observed, however, against secondarily generalized activity from focal seizures induced by pilocarpine and kainic acid, two chemoconvulsants that induce seizures that mimic some features of human complex partial seizures with secondary generalization. Levetiracetam also displayed inhibitory properties in the kindling model in rats, another model of human complex partial seizures, both during kindling development and in the fully kindled state. The predictive value of these animal models for specific types of human epilepsy is uncertain. Levetiracetam is thought to stimulate synaptic vesicle protein 2A (SV2A), inhibiting neurotransmitter release.

Dosage forms of Levetiracetam

DrugDosageQuantityPrice
Keppra250mg100 Regular Release Tablet$156.00
Keppra500mg100 Tablet$210.00
Keppra750mg120 Tablet$450.00
Keppra1000mg100 Regular Release Tablet$314.00
Keppra Oral Solution100mg/mL300mL Oral Solution$229.00
Levetiracetam250mg100 Tablet$49.00
Levetiracetam500mg60 Tablet$59.00
Levetiracetam750mg90 Tablet$82.00
Levetiracetam100mg/mL100mL Oral Solution$79.00

Prescription Generics

false

International Brands

Abbott-levetiracetam

Synonyms

Levetiracetam Levetiracetame

Manufacturers

Abbott Laboratories, Limited

CAS number

102767-28-2

UNII

44YRR34555

State

solid

Affected organisms

Humans and other mammals

Indication of Levetiracetam

Used as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy.

Toxicity of Levetiracetam

Side effects include aggression, agitation, coma, drowsiness, reduced consciousness, slowed breathing

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