Save up -80% on Levodopa
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Dopar
|price without discount in nearest pharmacy. Price may vary.|
We offer free Levodopa coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Levodopa every time. What are you waiting for? Claim your prescription drug card now!
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Levodopa volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Levodopa
The naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to dopamine. It is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.
Levodopa mechanism of action
Striatal dopamine levels in symptomatic Parkinson‘s disease are decreased by 60 to 80%, striatal dopaminergic neurotransmission may be enhanced by exogenous supplementation of dopamine through administration of dopamine’s precursor, levodopa. A small percentage of each levodopa dose crosses the blood-brain barrier and is decarboxylated to dopamine. This newly formed dopamine then is available to stimulate dopaminergic receptors, thus compensating for the depleted supply of endogenous dopamine.
Dosage forms of Levodopa
|Tablet, film coated||oral|
Apo-levocarb – Tab 10mg/100mg
Humans and other mammals
Indication of Levodopa
For the treatment of idiopathic Parkinson’s disease (Paralysis Agitans), postencephalitic parkinsonism, symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication, and manganese intoxication.
Toxicity of Levodopa
Oral, mouse: LD sub50 /sub = 2363 mg/kg; Oral, rabbit: LD sub50 /sub = 609 mg/kg; Oral, rat: LD sub50 /sub = 1780 mg/kg.
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