Save up -80% on Levodopa

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Levodopa

Levodopa powder

$7.31

g

* price without discount in nearest pharmacy. Price may vary.

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Levodopa volume of distribution

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What is Levodopa

The naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to dopamine. It is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.

Levodopa mechanism of action

Striatal dopamine levels in symptomatic Parkinson‘s disease are decreased by 60 to 80%, striatal dopaminergic neurotransmission may be enhanced by exogenous supplementation of dopamine through administration of dopamine’s precursor, levodopa. A small percentage of each levodopa dose crosses the blood-brain barrier and is decarboxylated to dopamine. This newly formed dopamine then is available to stimulate dopaminergic receptors, thus compensating for the depleted supply of endogenous dopamine.

Dosage forms of Levodopa

FormRouteStrength
Tabletoral25 mg/1
Tablet, film coatedoral
Gelintraintestinal (upper)
Prescription Generics

false

International Brands

Apo-levocarb – Tab 10mg/100mg

Synonyms

(-)-3-(3,4-Dihydroxyphenyl)-L-alanine (-)-Dopa

Manufacturers

Apotex Inc

CAS number

59-92-7

UNII

46627O600J

State

solid

Affected organisms

Humans and other mammals

Indication of Levodopa

For the treatment of idiopathic Parkinson’s disease (Paralysis Agitans), postencephalitic parkinsonism, symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication, and manganese intoxication.

Toxicity of Levodopa

Oral, mouse: LD sub50 /sub = 2363 mg/kg; Oral, rabbit: LD sub50 /sub = 609 mg/kg; Oral, rat: LD sub50 /sub = 1780 mg/kg.

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