Save up -80% on Levothyroxine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Synthroid
|$4.07||30 tablets/50 mcg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Levothyroxine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Levothyroxine every time. What are you waiting for? Claim your prescription drug card now!
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Levothyroxine volume of distribution
The volume of distribution is calculated to be about 10 to 12 l. Levothyroxine is approximately 99.97 % bound to specific transport proteins.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Levothyroxine
The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism.
Levothyroxine mechanism of action
Levothyroxine acts like the endogenous thyroid hormone thyroxine (T sub4 /sub, a tetra-iodinated tyrosine derivative). In the liver and kidney, T sub4 /sub is converted to T sub3 /sub, the active metabolite. In order to increase solubility, the thyroid hormones attach to thyroid hormone binding proteins, thyroxin-binding globulin, and thyroxin-binding prealbumin (transthyretin). Transport and binding to thyroid hormone receptors in the cytoplasm and nucleus then takes place. Thus by acting as a replacement for natural thyroxine, symptoms of thyroxine deficiency are relieved.
Dosage forms of Levothyroxine
Synthroid, Levoxyl, Levothroid, Unithroid, Tirosint, Levo-T
Aspen Pharma Trading Limited
Humans and other mammals
Indication of Levothyroxine
For use alone or in combination with antithyroid agents to treat hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor.
Toxicity of Levothyroxine
LD sub50 /sub=20 mg/kg (orally in rat). Hypermetabolic state indistinguishable from thyrotoxicosis of endogenous origin. Symptoms of thyrotoxicosis include weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, tachycardia, increased pulse and blood pressure, cardiac arrhythmias, tremors, insomnia, heat intolerance, fever, and menstrual irregularities.
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What is a Synthroid?
Synthroid is a medicine for the thyroid gland that replaces a hormone, usually produced by your thyroid gland, to regulate the body’s energy and metabolism. Levothyroxine is prescribed when the thyroid gland does not produce enough of this hormone on its own. Synthroid treats hypothyroidism (low thyroid hormone).
Synthroid is also used to treat or prevent goiter (an enlarged thyroid gland), which can be caused by hormonal imbalances, radiation therapy, surgery, or cancer.
You may not be able to take synthroid if you have certain medical conditions. Tell your doctor if you have an untreated or uncontrolled adrenal disorder, a thyroid disorder called thyrotoxicosis, or if you have recent or current symptoms of a heart attack.
Synthroid should not be used to treat obesity or weight problems. Dangerous side effects or death may occur due to improper use of levothyroxine, especially if you are taking any other medications for weight loss or appetite suppression.