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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Linzess

$437.5030 capsules/145 mcg
Price with discount in nearest pharmacy. Price may vary.

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Linaclotide volume of distribution

The volume of distribution of eptifibatide in patients with coronary artery disease is about 185–260 mL/kg, and is somewhat higher (220–270 mL/kg) in healthy individuals. The drug in the plasma is present largely in an unbound form, and the plasma elimination half-life is approximately 2.5 h.

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What is Linaclotide

Linaclotide is an orally administered, peptide agonist of guanylate cyclase 2C for the treatment of irritable bowel syndrome. Chemically, it is a heterodetic cyclic peptide and consists of fourteen amino acids. The protein sequence is as follows: Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr. There are three disulfide bonds which are located between Cys1 and Cys6; between Cys2 and Cys10; and between Cys5 and Cys13. FDA approved on August 30, 2012.

Linaclotide mechanism of action

Linaclotide is an agonist of guanylate cyclase-C (GC-C). Once linaclotide and its active metabolite binds to GC-C, it has local effect on the luminal surface of the intestinal epithelium. Activation of GC-C by linaclotide results in the intra- and extracellular increase of cyclic guanosine monophosphate concentrations (cGMP). This elevation of cGMP levels stimulates the secretion of chloride and bicarbonate into the intestinal lumen via activation of cystic fibrosis transmembrane conductance regulator (CFTR) ion channel. Ultimately, linaclotide helps patients with IBS (especially with constipation) as GI transit is accelerated and the release of intestinal fluid is increased. In animal models, a decrease in visceral pain after administration of linaclotide may be observed. A decrease in the activity of pain-sensing nerves occurs as a result of an increase in extracellular cGMP.

Dosage forms of Linaclotide

Capsuleoral145 mcg
Capsuleoral290 mcg
Capsule, hardOral use290 micrograms

Prescription Generics


International Brands



Cys cys glu tyr cys cys asn pro ala cys thr gly cys tyr (disulfide bridge: 1-6; 2-10; 5-13) L-Cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine cyclic (1-6),(2-10),(5-13)-tris(disulfide)


Forest Laboratories Canada Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Linaclotide

Treatment of irritable bowel syndrome (IBS) with constipation and chronic idiopathic constipation.

Toxicity of Linaclotide

Most common adverse reactions (incidence of at least 2%) reported in IBS-C or CIC patients are diarrhea, abdominal pain, flatulence and abdominal distension.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Linaclotide on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is a Linzess?

Linzess works by increasing the secretion of chloride and water in the intestines, which can soften stools and stimulate bowel movements.

Linzess is a prescription drug used to treat chronic constipation or chronic irritable bowel syndrome (IBS) in adults who have constipation as their main symptom. The safety and effectiveness of Linzess has not been established in patients under the age of 18 years.

You should not use Linzess if you have a blockage in the intestines. Linzess should not be given to a child under 6 years of age. Lynacloid can cause severe dehydration in a child.

Take Linzess in the morning on an empty stomach, at least 30 minutes before your first meal. Do not crush, do not chew, break or open the capsule. Swallow it all. Stop using Linzess and consult a doctor immediately if you have severe or persistent diarrhea, severe stomach pain or black, bloody or tarry stools.