Save up -80% on Linagliptin
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2018 Price of Linagliptin
* price without discount in nearest pharmacy. Price may vary.
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Linagliptin volume of distribution
Vd = 1110 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Linagliptin
Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes[Wikipedia]. Two pharmacological characteristics that sets linagliptin apart from other DPP-4 inhibitors is that it has a non-linear pharmacokinetic profile and is not primarily eliminated by the renal system. FDA approved on May 2, 2011.
Linagliptin mechanism of action
Linagliptin is a competitive and reversible dipeptidyl peptidase (DPP)-4 enzyme inhibitor that slows the breakdown of insulinotropic hormone glucagon-like peptide (GLP)-1 for better glycemic control in diabetes patients. GLP and glucose-dependent insulinotropic polypeptide (GIP) are incretin hormones that increase the production and release of insulin from pancreatic beta cells and decrease the release of glucagon from pancreatic alpha cells. This results in a overall decrease in glucose production in the liver and increase an of insulin in a glucose-dependent manner.
Dosage forms of Linagliptin
|Tablet, film coated||oral|
|Tablet, film coated, extended release||oral|
(R)-8-(3-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione BI 1356
Boehringer Ingelheim Pharmaceuticals, Inc.
Humans and other mammals
Indication of Linagliptin
Linagliptin is used for the management of type 2 diabetes mellitus.
Toxicity of Linagliptin
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