Save up -80% on Linagliptin

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Tradjenta

$377.7730 tablets/5 mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Tradjenta coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Linagliptin every time. What are you waiting for? Claim your prescription drug card now!

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Linagliptin volume of distribution

Distribution The mean apparent volume of distribution at steady state following a single intravenous dose of linagliptin 5 mg to healthy subjects is approximately 1110 L, indicating that linagliptin extensively distributes to the tissues.

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2018 Statistics

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Discount Cards 16,000+

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Total savings $4,735,080

What is Linagliptin

Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes[Wikipedia]. Two pharmacological characteristics that sets linagliptin apart from other DPP-4 inhibitors is that it has a non-linear pharmacokinetic profile and is not primarily eliminated by the renal system. FDA approved on May 2, 2011.

Linagliptin mechanism of action

Linagliptin is a competitive and reversible dipeptidyl peptidase (DPP)-4 enzyme inhibitor that slows the breakdown of insulinotropic hormone glucagon-like peptide (GLP)-1 for better glycemic control in diabetes patients. GLP and glucose-dependent insulinotropic polypeptide (GIP) are incretin hormones that increase the production and release of insulin from pancreatic beta cells and decrease the release of glucagon from pancreatic alpha cells. This results in a overall decrease in glucose production in the liver and increase an of insulin in a glucose-dependent manner.

Dosage forms of Linagliptin

FormRouteStrength
Tabletoral
Tablet, film coatedoral
Tablet, film coated, extended releaseoral

Prescription Generics

false

International Brands

Glyxambi

Synonyms

(R)-8-(3-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione BI 1356

Manufacturers

Boehringer Ingelheim Pharmaceuticals, Inc.

CAS number

668270-12-0

UNII

3X29ZEJ4R2

State

solid

Affected organisms

Humans and other mammals

Indication of Linagliptin

Linagliptin is used for the management of type 2 diabetes mellitus.

Toxicity of Linagliptin

The cause of possible liver injury during linagliptin therapy is not known. The drug is mostly metabolized by the liver, largely by the cytochrome P450 system (CYP 3A4), and a toxic or immunogenic intermediate of metabolism may be produced that could cause liver injury.

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What is Trajenta?

Trajenta is a relatively new class of antidiabetic drugs. DPP-4 inhibitors with an oral route of administration are successfully used to control type 2 diabetes; a large evidence base of its effectiveness has been accumulated. The active ingredient of the drug is linagliptin. Diabetics with kidney pathologies are especially appreciated for its benefits, since the drug does not put an additional burden on them.

The manufacturers, BOEHRINGER INGELHEIM PHARMA (Germany) and BOEHRINGER INGELHEIM ROXANE (USA), produce medicine in the form of convex round tablets of red color. On one side is the engraved symbol of the manufacturer, which protects the drug from counterfeit, on the other – the label “D5”. Each of them contains 5 mg of the active ingredient linagliptin and various fillers such as starch, dye, hypromellose, magnesium stearate, copovidone, macrogol.

The mechanism of action Trajenta is similar to the principles of operation of other analogues – Januvia, Galvus, Onglyza. GUI and GLP-1 are produced at the time of entry into the body of nutrients. The effectiveness of the drug is not associated with the stimulation of their production, the drug simply increases the duration of their exposure. Due to such characteristics, Trajenta, like other incontinomimetics, does not provoke the development of hypoglycemia and this is their significant advantage over other classes of hypoglycemic drugs.