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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Zyvox

$49.3120 tablets/600mg
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Linezolid volume of distribution

Once in the body, they show very different disposition Daptomycin has a very small volume of distribution whereas tigecycline has a volume of distribution of 7 L indicating very little tissue distribution of -350-500 L. Vancomycin and linezolid are in-between -with volumes of distribution of approximately 30 and 50 L.

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2018 Statistics

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Clients Benefit 29%

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Total savings $4,735,080

What is Linezolid

Linezolid is a synthetic antibiotic, the first of the oxazolidinone class, used for the treatment of infections caused by multi-resistant bacteria including streptococcus and methicillin-resistant Staphylococcus aureus (MRSA). The drug works by inhibiting the initiation of bacterial protein synthesis.

Linezolid mechanism of action

Linezolid is a synthetic antibacterial agent of the oxazolidinone class of antibiotics. It has in vitro activity against aerobic Gram positive bacteria, certain Gram negative bacteria and anaerobic microorganisms. It selectively inhibits bacterial protein synthesis through binding to sites on the bacterial ribosome and prevents the formation of a functional 70S-initiation complex. Specifically, linezolid binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex, which is an essential component of the bacterial translation process. The results of time-kill studies have shown linezolid to be bacteriostatic against enterococci and staphylococci. For streptococci, linezolid was found to be bactericidal for the majority of strains. Linezolid is also a reversible, nonselective inhibitor of monoamine oxidase. Therefore, linezolid has the potential for interaction with adrenergic and serotonergic agents.

Dosage forms of Linezolid

FormRouteStrength
Injection, solutionintravenous2 mg/mL
Powder, for suspensionoral100 mg/5mL
Tabletoral600 mg/1

Prescription Generics

true

International Brands

Apo-linezolid

Synonyms

Linezolid Linezolid

Manufacturers

Apotex Inc

CAS number

165800-03-3

UNII

ISQ9I6J12J

State

solid

Affected organisms

Gram negative and gram positive bacteria

Indication of Linezolid

For the treatment of bacterial infections caused by susceptible strains of vancomycin resistant iEnterococcus faecium /i, iStaphylococcal aureus /i (methicillin resistant and susceptible strains), iStreptococcus pneumoniae /i, iStreptococcus pyogenes /i, iStreptococcus agalactiae /i.

Toxicity of Linezolid

Clinical signs of acute toxicity lead to decreased activity, ataxia, vomiting and tremors.

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