Save up -80% on Lipoic Acid
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Strovite One
|Price with discount in nearest pharmacy. Price may vary.|
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Lipoic Acid volume of distribution
The highest AUC was found in subjects receiving Formulation C while the lowest AUC was found in subjects receiving Formulation A (AUC = 821±327 vs. 392±290 μg*min/mL; P = 0.037). Accordingly, a trend towards a faster oral clearance was found in patients receiving Formulation A compared to Formulation C and Formulation B (CL/F = 3849.9 ± 2800.6 mL/min vs. 1804.9 ± 1207.5 and 1860.5 ± 740.1 mL/min; P = 0.060). Volume of distribution was significantly higher in patients receiving Formulation A than the other formulations.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Lipoic Acid
Alpha-lipoic acid or ALA is a naturally occurring compound that’s made in the body. It serves vital functions at the cellular level, such as energy production. As long as you’re healthy, the body can produce all the ALA it needs for these purposes. Despite that fact, there has been a lot of recent interest in using ALA supplements. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss.
Lipoic Acid mechanism of action
Lipoic Acid is generally involved in oxidative decarboxylations of keto acids and is presented as a growth factor for some organisms. Lipoic acid exists as two enantiomers, the R-enantiomer and the S-enantiomer. Normally only the R-enantiomer of an amino acid is biologically active, but for lipoic acid the S-enantiomer assists in the reduction of the R-enantiomer when a racemic mixture is given. Some recent studies have suggested that the S-enantiomer in fact has an inhibiting effect on the R-enantiomer, reducing its biological activity substantially and actually adding to oxidative stress rather than reducing it. Furthermore, the S-enantiomer has been found to reduce the expression of GLUT-4s in cells, responsible for glucose uptake, and hence reduce insulin sensitivity.
Dosage forms of Lipoic Acid
Strovite One Caplets
1,2-dithiolane-3-pentanoic acid 1,2-dithiolane-3-valeric acid
Everett Laboratories, Inc.
Humans and other mammals
Indication of Lipoic Acid
For nutritional supplementation, also for treating dietary shortage or imbalance.
Toxicity of Lipoic Acid
Administration of 31.6 or 61.9mg ALA/kg bw/day for 4 weeks to male/female Wistar rats did not show any adverse effects. Specifically, there was no significant difference between control and treated animals at 31.6 or 61.9mg ALA/kg bw with regard to body weight gain, feed consumption, animal behaviour, or haematological and clinical chemistry parameters. Only the high-dose of 121mg ALA/kg bw was associated with slight alterations in liver enzymes as well as histopathological effects on the liver and mammary gland. ALA did not possess any mutagenic activity in the Ames assays conducted with various bacterial strains of Salmonella typhimurium. Moreover, there was no evidence of genotoxic activity in a mouse micronucleus assay. The results of these studies support the safety of ALA. The no-observed-adverse-effect level (NOAEL) is considered to be 61.9mg/kg bw/day.
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