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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Strovite One

$77.35g
Price with discount in nearest pharmacy. Price may vary.

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Lipoic Acid volume of distribution

The highest AUC was found in subjects receiving Formulation C while the lowest AUC was found in subjects receiving Formulation A (AUC = 821±327 vs. 392±290 μg*min/mL; P = 0.037). Accordingly, a trend towards a faster oral clearance was found in patients receiving Formulation A compared to Formulation C and Formulation B (CL/F = 3849.9 ± 2800.6 mL/min vs. 1804.9 ± 1207.5 and 1860.5 ± 740.1 mL/min; P = 0.060). Volume of distribution was significantly higher in patients receiving Formulation A than the other formulations.

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What is Lipoic Acid

Alpha-lipoic acid or ALA is a naturally occurring compound that’s made in the body. It serves vital functions at the cellular level, such as energy production. As long as you’re healthy, the body can produce all the ALA it needs for these purposes. Despite that fact, there has been a lot of recent interest in using ALA supplements. Advocates of ALA make claims that range from beneficial effects for treating conditions such as diabetes and HIV to enhancing weight loss.

Lipoic Acid mechanism of action

Lipoic Acid is generally involved in oxidative decarboxylations of keto acids and is presented as a growth factor for some organisms. Lipoic acid exists as two enantiomers, the R-enantiomer and the S-enantiomer. Normally only the R-enantiomer of an amino acid is biologically active, but for lipoic acid the S-enantiomer assists in the reduction of the R-enantiomer when a racemic mixture is given. Some recent studies have suggested that the S-enantiomer in fact has an inhibiting effect on the R-enantiomer, reducing its biological activity substantially and actually adding to oxidative stress rather than reducing it. Furthermore, the S-enantiomer has been found to reduce the expression of GLUT-4s in cells, responsible for glucose uptake, and hence reduce insulin sensitivity.

Dosage forms of Lipoic Acid

FormRouteStrength
Tabletoral

Prescription Generics

false

International Brands

Strovite One Caplets

Synonyms

1,2-dithiolane-3-pentanoic acid 1,2-dithiolane-3-valeric acid

Manufacturers

Everett Laboratories, Inc.

CAS number

62-46-4

UNII

73Y7P0K73Y

State

solid

Affected organisms

Humans and other mammals

Indication of Lipoic Acid

For nutritional supplementation, also for treating dietary shortage or imbalance.

Toxicity of Lipoic Acid

Administration of 31.6 or 61.9mg ALA/kg bw/day for 4 weeks to male/female Wistar rats did not show any adverse effects. Specifically, there was no significant difference between control and treated animals at 31.6 or 61.9mg ALA/kg bw with regard to body weight gain, feed consumption, animal behaviour, or haematological and clinical chemistry parameters. Only the high-dose of 121mg ALA/kg bw was associated with slight alterations in liver enzymes as well as histopathological effects on the liver and mammary gland. ALA did not possess any mutagenic activity in the Ames assays conducted with various bacterial strains of Salmonella typhimurium. Moreover, there was no evidence of genotoxic activity in a mouse micronucleus assay. The results of these studies support the safety of ALA. The no-observed-adverse-effect level (NOAEL) is considered to be 61.9mg/kg bw/day.

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