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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Zestril

$4.0130 tablets/20 mg
Price with discount in nearest pharmacy. Price may vary.

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Lisinopril volume of distribution

The volume of distribution appears to be slightly smaller than that in normal subjects.

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2018 Statistics

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Total savings $4,735,080

What is Lisinopril

Lisinopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Lisinopril may be used to treat hypertension and symptomatic congestive heart failure, to improve survival in certain individuals following myocardial infarction, and to prevent progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.

Lisinopril mechanism of action

There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE has two functionally active domains, N and C, which arise from tandem gene duplication. Although the two domains have high sequence similarity, they play distinct physiological roles. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domains, but have much greater affinity for and inhibitory activity against the C-domain. Lisinopril, one of the few ACE inhibitors that is not a prodrug, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI to ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as described in the Pharmacology section above. Lisinopril also causes an increase in plasma renin activity likely due to a loss of feedback inhibition mediated by ATII on the release of renin and/or stimulation of reflex mechanisms via baroreceptors.

Dosage forms of Lisinopril

DrugDosageQuantityPrice
Zestril10mg84 Tablet$85.00
Zestril20mg28 Tablet$35.00
Prinivil20mg84 Tablet$138.00
Lisinopril5mg84 Tablet$47.00
Lisinopril10mg84 Tablet$18.90
Lisinopril20mg84 Tablet$55.00
Lisinopril40mg100 Tablet$23.85
Zestoretic20/25mg100 Tablet$165.00
Zestoretic20/12.5mg84 Tablet$120.00
Lisinopril/Hctz10/12.5mg84 Tablet$65.00
Lisinopril/Hctz20/25mg90 Tablet$75.00
Lisinopril/Hctz10/12.5mg100 Tablet$62.00

Prescription Generics

false

International Brands

Act Lisinopril

Synonyms

(S)-1-(N(2)-(1-Carboxy-3-phenylpropyl)-L-lysyl)-L-proline (N2-((S)-1-CARBOXY-3-phenylpropyl)-L-lysyl-L-proline

Manufacturers

Actavis Pharma Company

CAS number

83915-83-7

UNII

E7199S1YWR

State

solid

Affected organisms

Humans and other mammals

Indication of Lisinopril

For the treatment of hypertension and symptomatic congestive heart failure. May be used in conjunction with thrombolytic agents, aspirin and/or beta;-blockers to improve survival in hemodynamically stable individuals following myocardial infarction. May be used to slow the progression of renal disease in hypertensive patients with diabetes mellitus and microalbuminuria or overt nephropathy.

Toxicity of Lisinopril

Symptoms of overdose include severe hypotension, electrolyte disturbances, and renal failure. LD sub50 /sub= 2000 mg/kg(orally in rat). Most frequent adverse effects include headache, dizziness, cough, fatigue and diarrhea.

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