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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Lomustine

Ceenu 10 mg capsule



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What is Lomustine

An alkylating agent of value against both hematologic malignancies and solid tumors.

Lomustine mechanism of action

Lomustine is a highly lipophilic nitrosourea compound which undergoes hydrolysis in vivo to form reactive metabolites. These metabolites cause alkylation and cross-linking of DNA (at the O6 position of guanine-containing bases) and RNA, thus inducing cytotoxicity. Other biologic effects include inhibition of DNA synthesis and some cell cycle phase specificity. Nitrosureas generally lack cross-resistance with other alkylating agents. As lomustine is a nitrosurea, it may also inhibit several key processes such as carbamoylation and modification of cellular proteins.

Dosage forms of Lomustine

Form Route Strength
Capsule oral 10 mg
Capsule oral 100 mg
Capsule oral 40 mg
Prescription Generics


International Brands



1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea 1-(2-Chloroethyl)-3-cyclohexylnitrosourea


Bristol Myers Squibb Canada

CAS number






Affected organisms

Humans and other mammals

Indication of Lomustine

For the treatment of primary and metastatic brain tumors as a component of combination chemotherapy in addition to appropriate surgical and/or radiotherapeutic procedures. Also used in combination with other agents as secondary therapy for the treatment of refractory or relapsed Hodgkin’s disease.

Toxicity of Lomustine

Oral, rat: LD sub50 /sub = 70 mg/kg. Pulmonary toxicity has been reported at cumulative doses usually greater than 1,100 mg/m2. There is one report of pulmonary toxicity at a cumulative dose of only 600 mg. The onset of toxicity has varied from 6 months after initiation of therapy, to as late as 15 years after.

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