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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Lomustine

Ceenu 10 mg capsule



* price without discount in nearest pharmacy. Price may vary.

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Lomustine volume of distribution

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What is Lomustine

An alkylating agent of value against both hematologic malignancies and solid tumors.

Lomustine mechanism of action

Lomustine is a highly lipophilic nitrosourea compound which undergoes hydrolysis in vivo to form reactive metabolites. These metabolites cause alkylation and cross-linking of DNA (at the O6 position of guanine-containing bases) and RNA, thus inducing cytotoxicity. Other biologic effects include inhibition of DNA synthesis and some cell cycle phase specificity. Nitrosureas generally lack cross-resistance with other alkylating agents. As lomustine is a nitrosurea, it may also inhibit several key processes such as carbamoylation and modification of cellular proteins.

Dosage forms of Lomustine

CeeNU10mg20 Capsule$189.00
CeeNU40mg20 Capsule$309.00
CeeNU100mg20 Capsule$499.00
Prescription Generics


International Brands



1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea 1-(2-Chloroethyl)-3-cyclohexylnitrosourea


Bristol Myers Squibb Canada

CAS number






Affected organisms

Humans and other mammals

Indication of Lomustine

For the treatment of primary and metastatic brain tumors as a component of combination chemotherapy in addition to appropriate surgical and/or radiotherapeutic procedures. Also used in combination with other agents as secondary therapy for the treatment of refractory or relapsed Hodgkin’s disease.

Toxicity of Lomustine

Oral, rat: LD sub50 /sub = 70 mg/kg. Pulmonary toxicity has been reported at cumulative doses usually greater than 1,100 mg/m2. There is one report of pulmonary toxicity at a cumulative dose of only 600 mg. The onset of toxicity has varied from 6 months after initiation of therapy, to as late as 15 years after.

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