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Price of Loratadine
Child’s claritin 5 mg tablet chew
* price without discount in nearest pharmacy. Price may vary.
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Loratadine volume of distribution
What is Loratadine
Loratadine is a derivative of azatadine and a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (histamine H1 antagonists) it lacks central nervous system depressing effects such as drowsiness. (PubChem)
Loratadine mechanism of action
Loratadine competes with free histamine and exhibits specific, selective peripheral H sub1 /sub antagonistic activity. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Loratadine has low affinity for cholinergic receptors and does not exhibit any appreciable alpha-adrenergic blocking activity in-vitro. Loratadine also appears to suppress the release of histamine and leukotrienes from animal mast cells, and the release of leukotrienes from human lung fragments, although the clinical importance of this is unknown.
Dosage forms of Loratadine
24 Hour Allergy Relief
Meijer Distribution Inc
Humans and other mammals
Indication of Loratadine
A self-medication that is used alone or in combination with pseudoephedrine sulfate for the symptomatic relief of seasonal allergic rhinitis. Also used for the symptomatic relief of pruritus, erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children under 6 unless directed by a clincian).
Toxicity of Loratadine
somnolence, tachycardia, and headache LD sub50 /sub=mg/kg (orally in rat)
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