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Price of Lorazepam
Lorazepam 2 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Lorazepam volume of distribution
1.3 L/kg. Unbound lorazepam can cross the blood-brain-barrier via passive diffusion.
What is Lorazepam
A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. (PubChem)
Lorazepam mechanism of action
Lorazepam binds to an allosteric site on GABA-A receptors, which are pentameric ionotropic receptors in the CNS. Binding potentiates the effects of the inhibitory neurotransmitter GABA, which upon binding opens the chloride channel in the receptor, allowing chloride influx and causing hyperpolerization of the neuron.
Dosage forms of Lorazepam
|Injection||intramuscular; intravenous||4 mg/mL|
Humans and other mammals
Indication of Lorazepam
For the management of anxiety disorders, and for treatment of status epilepticus.
Toxicity of Lorazepam
The most important clinical adverse event caused by lorazepam is respiratory depression. LD50, mouse, oral = 1850 mg/kg.
Disclaimer: before buying a Lorazepam on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.