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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Losartan

Cozaar 100 mg Tablet

$1.31

tablet

* price without discount in nearest pharmacy. Price may vary.

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Losartan volume of distribution

* 34 L (losartan, healthy subjects) * 12 L (active metabolite, healthy subjects)

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What is Losartan

Losartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. Losartan and its longer acting metabolite, E-3174, lower blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); they compete with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Losartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of systolic dysfunction, myocardial infarction, coronary artery disease, and heart failure.

Losartan mechanism of action

Losartan competitively inhibits the binding of angiotensin II to AT1 in many tissues including vascular smooth muscle and the adrenal glands. Losartan is metabolized to its active metabolite, E-3174, which is 10 to 40 times more potent than losartan and acts as a non-competitive AT1 antagonist. Inhibition of angiotensin II binding to AT1 inhibits its AT1-mediated vasoconstrictive and aldosterone-secreting effects and results in decreased vascular resistance and blood pressure. Losartan is 1,000 times more selective for AT1 than AT2. Inhibition of aldosterone secretion may increase sodium and water excretion while decreasing potassium excretion. Losartan is effective for reducing blood pressure and may be used to treat essential hypertension, left ventricular hypertrophy and diabetic nephropathy.

Dosage forms of Losartan

DrugDosageQuantityPrice
Cozaar25mg28 Tablet$57.00
Cozaar50mg84 Tablet$115.00
Cozaar100mg56 Tablet$32.00
Cozaar12.5mg84 Tablet$82.70
Losartan25mg84 Tablet$17.70
Losartan50mg84 Tablet$67.00
Losartan100mg84 Tablet$73.00
Hyzaar50/12.5mg84 Tablet$109.00
Hyzaar100/12.5mg28 Tablet$39.00
Hyzaar DS100/25mg56 Tablet$59.70
Hyzaar DS100/25mg84 Tablet$86.25
Losartan/Hctz100/25mg100 Tablet$102.00
Losartan/Hctz50/12.5mg100 Tablet$73.00
Losartan/Hctz100/12.5mg84 Tablet$99.00
Prescription Generics

false

International Brands

Act Losartan

Synonyms

(2-Butyl-4-chloro-1-{(2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl}-1H-imidazol-5-yl)methanol 2-N-Butyl-4-chloro-5-hydroxymethyl-1-((2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)imidazole

Manufacturers

Actavis Pharma Company

CAS number

114798-26-4

UNII

JMS50MPO89

State

solid

Affected organisms

Humans and other mammals

Indication of Losartan

May be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. May be used as a first line agent to delay progression of diabetic nephropathy. Losartan may be also used as a second line agent in the treatment of congestive heart failure, systolic dysfunction, myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors.

Toxicity of Losartan

Hypotension and tachycardia; Bradycardia could occur from parasympathetic (vagal) stimulation, LD sub50 /sub= 1000 mg/kg (orally in rat)

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