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Price of Lutropin alfa
Luveris 75 unit vial
* price without discount in nearest pharmacy. Price may vary.
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Lutropin alfa volume of distribution
The steady state volume of distribution is around 10-14 L.
What is Lutropin alfa
Lutropin alfa is a recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 residues, beta = 121 residues. It is a heterodimeric glycoprotein. Each monomeric unit is a glycoprotein molecule. In females, an acute rise of LH (“LH surge”) triggers ovulation and the development of the corpus luteum. In males, it stimulates Leydig cell production of testosterone. Lutropin alfa was the first and only recombinant human form of luteinizing hormone (LH) developed for use in the stimulation of follicular development.
Lutropin alfa mechanism of action
Luteinizing hormone binds to a receptor shared with the human chorionic gonadotropin hormone (hCG) on the ovarian theca (and granulosa) cells and testicular Leydig cells. This LH/CG transmembrane receptor is a member of the super-family of G protein-coupled receptors. Adenylate cyclase then activates many other pathways leading to steroid hormone production and other follicle maturation processes.
Dosage forms of Lutropin alfa
|Liquid; powder for solution||intramuscular|
|Powder for solution||subcutaneous||75 unit|
Humegon Inj 75 I.U.
Insterstiial cell-stimulating hormone
Organon Canada Ltd Ltee
Humans and other mammals
Indication of Lutropin alfa
For treatment of infertility in women with hypothalamic or pituitary insufficiency (hypogonadotropic hypogonadism) and profound LH deficiency (LH 1.2 international units IU/L)
Toxicity of Lutropin alfa
Lutropin alfa is not indicated for people under 16 and over 60, pregnant and lactating women, patients with uncontrolled thyroid and adrenal failure, patients with active, untreated tumours of the hypothalamus and pituitary gland, and in any patient with a condition that makes a normal pregnancy possible such as primary ovarian failure or fibroid tumors of the uterus.
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