Save up -80% on Macitentan
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Opsumit
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Macitentan coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Macitentan every time. What are you waiting for? Claim your prescription drug card now!
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Macitentan volume of distribution
Macitentan has a volume of distribution of 50L. Macitentan is metabolised to an active metabolite by CYP 3A4 (major) and CYP 2C19 (minor). Eliminated 50% through urine and 24% through feces. The half life of macitentan is 16 hours, and the half life of it’s active metabolite is 48 hours
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Macitentan
Macitentan was approved in October 2013. It is indicated for patients with pulmonary arterial hypertension, and is marketed under the brand name Opsumit. Macitentan is an antagonist/blocker of endothelin receptors on blood vessels and smooth muscle, and, thus, blocks the stimulation of vasculature hypertrophy, inflammation, fibrosis, proliferation, and vasoconstriction. Similar to all drugs acting on the renin-angiotensin system, macitentan is associated with embryo and fetal toxicity, so it should not be used in pregnancy and has special precautions that must be followed for all females of child-bearing age.
Macitentan mechanism of action
Macitentan is an antagonist/blocker of endothelin receptors. Endothelin receptors are found in the endothelial cells of blood vessels and smooth muscle. Macitentan binds to the receptors, endothelin A and B (ETA and ETB), which prevents the agonist endothelin -1 (ET-1) from binding and stimulating the ETA and ETB receptors.
Dosage forms of Macitentan
Actelion Pharmaceuticals US, Inc.
Humans and other mammals
Indication of Macitentan
Macitentan is indicated for patients with pulmonary arterial hypertension.
Toxicity of Macitentan
Macitentan has a black box warning of embryo-fetal toxicity. Special precautions must be taken for all females of child-bearing age, and women who are pregnant must not be given macitentan.
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