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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Prepopik

$143.631 carton (2 packets) 3.5 mg
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Magnesium oxide volume of distribution

Serum magnesium increased moderately during exposure and returned to the initial level 25 days after the end of the exposure. There was a significant increase in magnesium excretion with urine. The findings showed that inhaled dust was gradually dissolved in the body. The magnesium content was evaluated in the reticuloendothelial organs (liver and spleen) 25 days after the last exposure and was found to increase by 20.1% in the spleen and by 15.6% in the liver. A concomitant histological exam of internal organs confirmed that the dust was retained in the lungs (without fibrotic changes), that particles were present in the spleen (sinusoid macrophages) and that the red pulp was hemorrhagic. No signs of pulmonary fibrosis were found even after 6 months after the last exposure. Dust particles were found in thickened interalveolar septa and macrophages. Proliferative histiocytic elements with particles present were found in the subcapsular sinuses and medulla of hilus lymphatic nodes. The findings showed that magnesite dust was eliminated by both blood and lymph.

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What is Magnesium oxide

Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.

Magnesium oxide mechanism of action

The term “Milk of Magnesia” was first used to describe a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestion and heartburn. When taken internally by mouth as a laxative, the osmotic force of the magnesia suspension acts to draw fluids from the body and to retain those already within the lumen of the intestine, serving to distend the bowel, thus stimulating nerves within the colon wall, inducing peristalsis and resulting in evacuation of colonic contents. Magnesium supplements have also been shown to reduce platelet aggregation by inhibiting in the influx of calcium, a crucial component of platelet aggregation.

Dosage forms of Magnesium oxide

FormRouteStrength
Kit
Capsuleoral
Liquidoral1.75 g

Prescription Generics

false

International Brands

Active Fe

Synonyms

Magmitt

Manufacturers

Gm Pharmaceuticals, Inc.

CAS number

1309-48-4

UNII

3A3U0GI71G

State

solid

Affected organisms

Indication of Magnesium oxide

Magnesium hydroxide is used as a laxative to relieve occasional constipation (irregularity) and as an antacid to relieve indigestion, sour stomach, and heartburn.

Toxicity of Magnesium oxide

Bronchoalveolar lavage (BAL) cell and cytokine concentrations, pulmonary function, and peripheral blood neutrophil concentrations /were quantified/ in 6 healthy volunteers 18-20 hr after inhalation of fine and ultrafine magnesium oxide particles produced from a furnace system model. Postexposure studies /were compared/ with control studies from the same 6 subjects. Mean +/- standard deviation (SD) cumulative magnesium dose was 4,138 +/- 2,163 min x mg/cu m. By weight, 28% of fume particles were ultrafine (<0.1 micron in diameter) and over 98% of fume particles were fine (<2.5 micron in diameter). There were no significant differences in BAL inflammatory cell concentrations, BAL interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor, pulmonary function, or peripheral blood neutrophil concentrations postexposure compared with control.

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What is Prepopic?

The US Food and Drug Administration approved Prepopic (sodium picosulfate, magnesium oxide, and citric acid) to help clean the colon in adults preparing for colonoscopy.

A single dose of Prepopik consists of two packets of powder, each of which is dissolved in cold water and taken at different times. Patients should take Prepopic on the night before colonoscopy and in the morning colonoscopy (split-dose regimen). If this is not possible, patients can take Prepopic during the day and evening before a colonoscopy.

As part of this colon cleaning regimen, patients taking Prepopik should consume extra fluids during and after use. Additional fluid intake is also important to reduce the risk of fluid and electrolyte imbalance. The most common side effects in adult patients taking Prepopik are nausea, headache, and vomiting.

Read Prepopic’s guide before you start taking this medicine, and every time you get a refill. There may be new information. This information does not replace a conversation with your health care provider about your medical condition or your treatment.