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2018 Price of Malathion
Malathion 0.5% lotion
* price without discount in nearest pharmacy. Price may vary.
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Malathion volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Malathion
Malathion is a parasympathomimetic organophosphate compound that is used as an insecticide for the treatment of head lice. Malathion is an irreversible cholinesterase inhibitor and has low human toxicity.
Malathion mechanism of action
Malathion is a nonsystemic, wide-spectrum organophosphate insecticide. It inhibits acetylcholinesterase activity of most eukaryotes. Malathion is toxic to aquatic organisms, but has a relatively low toxicity for birds and mammals. The major metabolites of malathion are mono- and di-carboxylic acid derivatives, and malaoxon is a minor metabolite. However, it is malaoxon that is the strongest cholinesterase inhibitor. Cholinesterases catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. Because of its essential function, chemicals that interfere with the action of cholinesterase are potent neurotoxins, causing muscle spasms and ultimately death.
Dosage forms of Malathion
((Dimethoxyphosphinothioyl)thio)butanedioic acid diethyl ester Carbophos
Taro Pharmaceuticals U.S.A., Inc.
Indication of Malathion
For patients infected with Pediculus humanus capitis (head lice and their ova) of the scalp hair.
Toxicity of Malathion
Malathion is slightly toxic via the oral route, with reported oral LDsub50/sub values of 1000 mg/kg to greater than 10,000 mg/kg in the rat. It is also slightly toxic via the dermal route, with reported dermal LDsub50/sub values of greater than 4000 mg/kg in rats. Moderate poisoning can result in chest tightness, difficulty breathing, bradycardia, tachycardia, tremor/ataxia, blurred vision, and confusion. Severe, life-threatening signs include coma, seizures, respiratory arrest, and paralysis. Malathion may also be irritating to the skin and eyes.
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