Save up -80% on Maraviroc
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Selzentry
|price without discount in nearest pharmacy. Price may vary.|
We offer free Maraviroc coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Maraviroc every time. What are you waiting for? Claim your prescription drug card now!
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Maraviroc volume of distribution
The volume of distribution of maraviroc is ∼194 L. Absorption of maraviroc is rapid but variable, with the time to maximum absorption generally being 1–4 h after receipt of the drug.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Maraviroc
Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Maraviroc name as it entered trials. It was approved for use by the FDA in August, 2007.
Maraviroc mechanism of action
Maraviroc is an entry inhibitor and works by blocking HIV from entering human cells. Specifically maraviroc is a selective, slowly reversible, small molecule antagonist of the interaction between human CCR5 and HIV-1 gp120. Maraviroc selectively binds to the human chemokine receptor CCR5 present on the membrane of CD4 cells (T-cells), preventing the interaction of HIV-1 gp120 and CCR5 necessary for CCR5-tropic HIV-1 to enter cells.
Dosage forms of Maraviroc
|Film-coated tablet||Oral use||150 mg|
|Film-coated tablet||Oral use||300 mg|
Viiv Healthcare Ulc
Human Immunodeficiency Virus
Indication of Maraviroc
For treatment-experienced adult patients infected with only CCR5-tropic HIV-1 detectable, who have evidence of viral replication and HIV-1 strains resistant to multiple antiretroviral agents.
Toxicity of Maraviroc
Maraviroc is a small molecule antagonist of the CCR5 receptor with potent in vitro antiviral activity (IC90 of ∼2 nmol/L). In animal studies there were no signs of immunotoxicity with doses up to 300 mg/kg per day. It is safe and well tolerated in healthy volunteers.
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