Save up -80% on Mecasermin

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Mecasermin

Increlex 40 mg/4 ml vial

$232.8ml
price without discount in nearest pharmacy. Price may vary.

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Mecasermin volume of distribution

* 0.257 0.073 L/kg (subjects with severe Primary IGFD)

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About RX24Drugs

2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Mecasermin

Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1). IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is synthesized in bacteria (E. coli) that have been modified by the addition of the gene for human IGF-1.

Mecasermin mechanism of action

Mecasermin supplies recombinant-DNA-origin IGF-1, which binds to the Type I IGF-1 receptor. This receptor exerts intra-cellular signaling activity in a number of processes involved in statural growth, including mitogenesis in multiple tissue types, chondrocyte growth and division along cartilage growth plates, and increases in organ growth.

Dosage forms of Mecasermin

FormRouteStrength
Injection, solutionsubcutaneous40 mg/4mL

Prescription Generics

false

International Brands

Increlex

Synonyms

IGF-1 IGF1

Manufacturers

Ipsen Biopharmaceuticals, Inc.

CAS number

68562-41-4

UNII

7GR9I2683O

State

liquid

Affected organisms

Humans and other mammals

Indication of Mecasermin

For the long-term treatment of growth failure in pediatric patients with Primary IGFD or with GH gene deletion who have developed neutralizing antibodies to GH. It is not indicated to treat Secondary IGFD resulting from GH deficiency, malnutrition, hypothyroidism or other causes; it is not a substitute for GH therapy.

Toxicity of Mecasermin

There is no clinical experience with overdosage of mecasermin. Based on known pharmacological effects, acute overdosage would be predicted to lead to hypoglycemia. Long-term overdosage may result in signs and symptoms of acromegaly.

RX24 Drugs Disclaimer: before buying a Mecasermin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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