Save up -80% on Mechlorethamine

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Mechlorethamine

Mustargen 10 mg vial

$178.71vial
price without discount in nearest pharmacy. Price may vary.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Mechlorethamine

A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin’s disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL) in patients who have received prior skin-directed therapy. Each tube of Valchlor contains 0.016% of mechlorethamine which is equivalent to 0.02% mechlorethamine HCL.

Mechlorethamine mechanism of action

Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. Mechlorethamine is cell cycle phase-nonspecific.

Dosage forms of Mechlorethamine

FormRouteStrength
Powder for solutionintravenous10 mg
Powder, for solutionintracavitary; intravenous10 mg/10mL
Geltopical.012 g/60g

Prescription Generics

false

International Brands

Mustargen

Synonyms

2,2′-dichloro-N-methyldiethylamine beta,Beta’-dichlorodiethyl-N-methylamine

Manufacturers

Lundbeck LLC

CAS number

51-75-2

UNII

50D9XSG0VR

State

solid

Affected organisms

Humans and other mammals

Indication of Mechlorethamine

For the palliative treatment of Hodgkin’s disease (Stages III and IV), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, and bronchogenic carcinoma. Also for the palliative treatment of metastatic carcinoma resulting in effusion.

Toxicity of Mechlorethamine

Symptoms of overexposure include severe leukopenia, anemia, thrombocytopenia, and a hemorrhagic diathesis with subsequent delayed bleeding may develop. Death may follow. The most common adverse reactions (.5%) of the topical formulation are dermatitis, pruritus, bacterial skin infection, skin ulceration or blistering, and hyperpigmentation. The oral LD50 for a rat is 10 mg/kg.

RX24 Drugs Disclaimer: before buying a Mechlorethamine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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