Save up -80% on Medroxyprogesterone acetate

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Depo-Provera

$215.061 vial (1ml) 150mg/ml
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Medroxyprogesterone acetate volume of distribution

PA was distributed very rapidly into three compartments after i.v. injections, revealing half-lives of 4-7 h. Using a nonlinear model fitting metabolic clearance rates (MCR) were found to be 652 1/day before and 601 1/day during MPA treatment, and distribution volumes (V0) 5.9 and 3.41 respectively. The major metabolite of MPA following i.v. injection was a glucuronide of MPA, presumably of the 3-enol form. After oral administration the radioactivity in serum increased rapidly and reached a plateau of about 1% of the dose per litre serum after approx 2 h.

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Clients Benefit 29%

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Total savings $4,735,080

What is Medroxyprogesterone acetate

Medroxyprogesterone acetate (INN, USAN, BAN), also known as 17-hydroxy-6-methylprogesterone acetate, and commonly abbreviated as MPA, is a steroidal progestin, a synthetic variant of the human hormone progesterone. It is used as a contraceptive, in hormone replacement therapy and for the treatment of endometriosis as well as several other indications. MPA is a more potent derivative of its parent compound medroxyprogesterone (MP). While medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, what is normally being administered is MPA and not MP. (Wikipedia)

Medroxyprogesterone acetate mechanism of action

Progestins diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge.

Dosage forms of Medroxyprogesterone acetate

DrugDosageQuantityPrice
Provera2.5mg100 Tablet$55.00
Provera5mg100 Tablet$69.00
Provera10mg101 Tablet$95.00

Prescription Generics

true

International Brands

Apo-medroxy

Synonyms

(6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-dione 17-Acetoxy-6alpha-methylprogesterone

Manufacturers

Apotex Inc

CAS number

71-58-9

UNII

C2QI4IOI2G

State

solid

Affected organisms

Humans and other mammals

Indication of Medroxyprogesterone acetate

Used as a contraceptive and to treat secondary amenorrhea, abnormal uterine bleeding, pain associated with endometriosis, endometrial and renal cell carcinomas, paraphilia in males, GnRH-dependent forms of precocious puberty, as well as to prevent endometrial changes associated with estrogens.

Toxicity of Medroxyprogesterone acetate

Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.

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