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Price of Medroxyprogesterone acetate
Provera 2.5 mg tablet
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Medroxyprogesterone acetate volume of distribution
What is Medroxyprogesterone acetate
Medroxyprogesterone acetate (INN, USAN, BAN), also known as 17-hydroxy-6-methylprogesterone acetate, and commonly abbreviated as MPA, is a steroidal progestin, a synthetic variant of the human hormone progesterone. It is used as a contraceptive, in hormone replacement therapy and for the treatment of endometriosis as well as several other indications.
MPA is a more potent derivative of its parent compound medroxyprogesterone (MP). While medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate, what is normally being administered is MPA and not MP. (Wikipedia)
Medroxyprogesterone acetate mechanism of action
Progestins diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge.
Dosage forms of Medroxyprogesterone acetate
|Injection, suspension||intramuscular||400 mg/mL|
Humans and other mammals
Indication of Medroxyprogesterone acetate
Used as a contraceptive and to treat secondary amenorrhea, abnormal uterine bleeding, pain associated with endometriosis, endometrial and renal cell carcinomas, paraphilia in males, GnRH-dependent forms of precocious puberty, as well as to prevent endometrial changes associated with estrogens.
Toxicity of Medroxyprogesterone acetate
Side effects include loss of bone mineral density, BMD changes in adult women, bleeding irregularities, cancer risks, and thromboembolic disorders.
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