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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Lariam

$32.88 tablets/250 mg
Price with discount in nearest pharmacy. Price may vary.

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Mefloquine volume of distribution

Mefloquine has a large apparent volume of distribution of 200 L and is highly bound (98%) to plasma proteins. The elimination is slow; the terminal half-life is 13 10 to 14 days in Thai patients with falciparum malaria. Vomiting within 1 hour of drug administration has an influence on blood concentrations of mefloquine and this may result in treatment failure. The whole blood concentrations of mefloquine on the first two days of treatment are important determinants of parasitological response. There appear to be no pharmacokinetic interactions between mefloquine and the other two components of Fansimef in patients with uncomplicated falciparum malaria.

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2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Mefloquine

A phospholipid-interacting antimalarial drug (antimalarials). It is very effective against plasmodium falciparum with very few side effects.

Mefloquine mechanism of action

Mefloquine has been found to produce swelling of the i Plasmodium falciparum /i food vacuoles. It may act by forming toxic complexes with free heme that damage membranes and interact with other plasmodial components.

Dosage forms of Mefloquine

Tabletoral250 mg
Tabletoral250 mg/1

Prescription Generics


International Brands

Lariam Tab 250mg


((R*,S*)-2,8-bis(trifluoromethyl)quinolin-4-yl)-(2-piperidyl)methanol alpha-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol


Hoffmann La Roche Limited

CAS number






Affected organisms


Indication of Mefloquine

For the treatment of mild to moderate acute malaria caused by Mefloquineuine-susceptible strains of i Plasmodium falciparum /i (both chloroquine-susceptible and resistant strains) or by i Plasmodium vivax /i . Also for the prophylaxis of i Plasmodium falciparum /i and i Plasmodium vivax /i malaria infections, including prophylaxis of chloroquine-resistant strains of i Plasmodium falciparum /i .

Toxicity of Mefloquine

Oral, rat: LD sub 50 /sub = 880 mg/kg. Symptoms of overdose include nausea, vomiting, and weight loss.

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