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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Megestrol acetate

Megestrol Acetate 40 mg tablet

$1.15

tablet

* price without discount in nearest pharmacy. Price may vary.

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Megestrol acetate volume of distribution

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What is Megestrol acetate

17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.

Megestrol acetate mechanism of action

The precise mechanism by which megestrol acetate produces effects in anorexia and cachexia is unknown at the present time, but its progestin antitumour activity may involve suppression of luteinizing hormone by inhibition of pituitary function. Studies also suggest that the megestrol’s weight gain effect is related to its appetite-stimulant or metabolic effects rather than its glucocorticoid-like effects or the production of edema. It has also been suggested that megestrol may alter metabolic pathyways via interferences with the production or action of mediators such as cachectin, a hormone that inhibits adipocyte lipogenic enzymes.

Dosage forms of Megestrol acetate

FormRouteStrength
Suspensionoral125 mg/mL
Suspensionoral40 mg
Tabletoral160 mg
Prescription Generics

true

International Brands

Apo-megestrol

Synonyms

17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate

Manufacturers

Apotex Inc

CAS number

595-33-5

UNII

TJ2M0FR8ES

State

solid

Affected organisms

Humans and other mammals

Indication of Megestrol acetate

For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used for the palliative management of recurrent, inoperable, or metastatic breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.

Toxicity of Megestrol acetate

No serious unexpected side effects have resulted from studies involving megestrol acetate oral suspension administered in dosages as high as 1200 mg/day. Treatment with megestrol acetate, an orexigenic agent, has also resulted in iatrogenic adrenal suppression. The mechanism is presumably related to the glucocorticoid properties of megestrol acetate (PMID: 12872362).

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