Save up -80% on Megestrol acetate
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2018 Price of Megestrol acetate
Megestrol Acetate 40 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Megestrol acetate volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Megestrol acetate
17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Megestrol acetate mechanism of action
The precise mechanism by which megestrol acetate produces effects in anorexia and cachexia is unknown at the present time, but its progestin antitumour activity may involve suppression of luteinizing hormone by inhibition of pituitary function. Studies also suggest that the megestrol’s weight gain effect is related to its appetite-stimulant or metabolic effects rather than its glucocorticoid-like effects or the production of edema. It has also been suggested that megestrol may alter metabolic pathyways via interferences with the production or action of mediators such as cachectin, a hormone that inhibits adipocyte lipogenic enzymes.
Dosage forms of Megestrol acetate
17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate
Humans and other mammals
Indication of Megestrol acetate
For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used for the palliative management of recurrent, inoperable, or metastatic breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries.
Toxicity of Megestrol acetate
No serious unexpected side effects have resulted from studies involving megestrol acetate oral suspension administered in dosages as high as 1200 mg/day. Treatment with megestrol acetate, an orexigenic agent, has also resulted in iatrogenic adrenal suppression. The mechanism is presumably related to the glucocorticoid properties of megestrol acetate (PMID: 12872362).
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