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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Alkeran

$155.5550 tablets/2mg
price without discount in nearest pharmacy. Price may vary.

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Melphalan volume of distribution

The apparent volume of the central compartment was 12.8 ± 4.3 l, and the total volume of distribution was 0.62 ± 0.21 l/kg. Very variable absorption was seen in the same patients after receiving 5–12 mg melphalan p.o. The half-life of the absorption phase varied from 2.1 to 62.1 min (22.8 ± 18.1 min) with delays (before absorption started) of 0–113 min. The fraction of dose absorbed varied from 0.32 to 1.03 (0.72 ± 0.23), and the half-life of the β phase was 92 ± 27 min. The type of breakfast eaten before p.o. melphalan was found to correlate with the fraction of drug absorbed.

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2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Melphalan

An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer – melphalan, the racemic mixture – merphalan, and the dextro isomer – medphalan; toxic to bone marrow, but little vesicant action; potential carcinogen.

Melphalan mechanism of action

Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases (primarily at the N-7 position of guanine and to a lesser extent, at the N-3 position of adenine), forming monoadducts and resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.

Dosage forms of Melphalan

FormRouteStrength
Tabletoral2 mg
Tablet, film coatedoral2 mg/1
Injection, powder, lyophilized, for solutionintravenous50 mg/10mL

Prescription Generics

false

International Brands

Alkeran

Synonyms

3-(P-(Bis(2-chloroethyl)amino)phenyl)-L-alanine 3-P-(Di(2-chloroethyl)amino)-phenyl-L-alanine

Manufacturers

Apo Pharma Usa, Inc

CAS number

148-82-3

UNII

Q41OR9510P

State

solid

Affected organisms

Humans and other mammals

Indication of Melphalan

For the palliative treatment of multiple myeloma and for the palliation of non-resectable epithelial carcinoma of the ovary. Has also been used alone or as part of various chemotherapeutic regimens as an adjunct to surgery in the treatment of breast cancer, alone or in combination regimens for palliative treatment of locally recurrent or unresectable in-transit metastatic melanoma of the extremities, as well as for the treatment of amyloidosis with prednisone.

Toxicity of Melphalan

Vomiting, ulceration of the mouth, diarrhea, and hemorrhage of the gastrointestinal tract; The principal toxic effect is bone marrow suppression. LD sub 50 /sub =11.2 mg/kg (orally in rat)

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