Save up -80% on Melphalan
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Melphalan
Alkeran 2 mg tablet
|price without discount in nearest pharmacy. Price may vary.|
We offer free Melphalan coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Melphalan every time. What are you waiting for? Claim your prescription drug card now!
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Melphalan volume of distribution
* 0.5 L/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Melphalan
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer – melphalan, the racemic mixture – merphalan, and the dextro isomer – medphalan; toxic to bone marrow, but little vesicant action; potential carcinogen.
Melphalan mechanism of action
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases (primarily at the N-7 position of guanine and to a lesser extent, at the N-3 position of adenine), forming monoadducts and resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
Dosage forms of Melphalan
|Tablet, film coated||oral||2 mg/1|
|Injection, powder, lyophilized, for solution||intravenous||50 mg/10mL|
Apo Pharma Usa, Inc
Humans and other mammals
Indication of Melphalan
For the palliative treatment of multiple myeloma and for the palliation of non-resectable epithelial carcinoma of the ovary. Has also been used alone or as part of various chemotherapeutic regimens as an adjunct to surgery in the treatment of breast cancer, alone or in combination regimens for palliative treatment of locally recurrent or unresectable in-transit metastatic melanoma of the extremities, as well as for the treatment of amyloidosis with prednisone.
Toxicity of Melphalan
Vomiting, ulceration of the mouth, diarrhea, and hemorrhage of the gastrointestinal tract; The principal toxic effect is bone marrow suppression. LD sub 50 /sub =11.2 mg/kg (orally in rat)
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