Save up -80% on Memantine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Namenda
|price without discount in nearest pharmacy. Price may vary.|
We offer free Namenda coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Memantine every time. What are you waiting for? Claim your prescription drug card now!
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Memantine volume of distribution
The apparent volume of distribution of memantine is approximately 9-11 L/kg and the plasma protein binding is approximately 45%.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Memantine
Memantine is an amantadine derivative with low to moderate-affinity for NMDA receptors. It is a noncompetitive NMDA receptor antagonist that binds preferentially to NMDA receptor-operated cation channels. It blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction. It is under investigation for the treatment of Alzheimer’s disease, but there has been no clinical support for the prevention or slowing of disease progression.
Memantine mechanism of action
Memantine exerts its action through uncompetitive NMDA receptor antagonism, binding preferentially to the NMDA receptor-operated cation channels. Prolonged increased levels of glutamate in the brain of demented patients are sufficient to counter the voltage-dependent block of NMDA receptors by Mg sup 2+ /sup ions and allow continuous influx of Ca sup 2+ /sup ions into cells, ultimately resulting in neuronal degeneration. Studies suggest that memantine binds more effectively than Mg sup 2+ /sup ions at the NMDA receptor, and thereby effectively blocks this prolonged influx of Ca sup 2+ /sup ions through the NMDA channel whilst preserving the transient physiological activation of the channels by higher concentrations of synaptically released glutamate. Thus memantine protects against chronically elevated concentrations of glutamate. Memantine also has antagonistic activity at the type 3 serotonergic (5-HT sub 3 /sub ) receptor with a potency that is similar to that at the NMDA receptor, and lower antagonistic activity at the nicotinic acetylcholine receptor. This drug has no affinity for -aminobutyric acid (GABA), benzodiazepine, dopamine, adrenergic, histamine, or glycine receptors or for voltage-dependent calcium, sodium, or potassium channels.
Dosage forms of Memantine
|Film-coated tablet||Oral use||10 mg|
|Film-coated tablet||Oral use||20 mg|
Actavis Pharma Company
Humans and other mammals
Indication of Memantine
For the treatment of moderate to severe dementia of the Alzheimer’s type.
Toxicity of Memantine
Side effects include pain, abnormal crying, leg pain, fever, increased apetite. Adverse drug reactions include: dizziness, confusion, headache, hallucinations, tiredness. Less common side effects include: vomiting, anxiety, hypertonia, cystitis, and increased libido. Doses of up to 400 mg have been tolerated.
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