Save up -80% on Memantine

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Memantine

Namenda 5 mg tablet

$3.32

tablet

* price without discount in nearest pharmacy. Price may vary.

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Memantine volume of distribution

* 9 to 11 L/kg

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What is Memantine

Memantine is an amantadine derivative with low to moderate-affinity for NMDA receptors. It is a noncompetitive NMDA receptor antagonist that binds preferentially to NMDA receptor-operated cation channels. It blocks the effects of excessive levels of glutamate that may lead to neuronal dysfunction. It is under investigation for the treatment of Alzheimer’s disease, but there has been no clinical support for the prevention or slowing of disease progression.

Memantine mechanism of action

Memantine exerts its action through uncompetitive NMDA receptor antagonism, binding preferentially to the NMDA receptor-operated cation channels. Prolonged increased levels of glutamate in the brain of demented patients are sufficient to counter the voltage-dependent block of NMDA receptors by Mg sup 2+ /sup ions and allow continuous influx of Ca sup 2+ /sup ions into cells, ultimately resulting in neuronal degeneration. Studies suggest that memantine binds more effectively than Mg sup 2+ /sup ions at the NMDA receptor, and thereby effectively blocks this prolonged influx of Ca sup 2+ /sup ions through the NMDA channel whilst preserving the transient physiological activation of the channels by higher concentrations of synaptically released glutamate. Thus memantine protects against chronically elevated concentrations of glutamate. Memantine also has antagonistic activity at the type 3 serotonergic (5-HT sub 3 /sub ) receptor with a potency that is similar to that at the NMDA receptor, and lower antagonistic activity at the nicotinic acetylcholine receptor. This drug has no affinity for -aminobutyric acid (GABA), benzodiazepine, dopamine, adrenergic, histamine, or glycine receptors or for voltage-dependent calcium, sodium, or potassium channels.

Dosage forms of Memantine

FormRouteStrength
Tabletoral5 mg
Film-coated tabletOral use10 mg
Film-coated tabletOral use20 mg
Prescription Generics

false

International Brands

Act Memantine

Synonyms

1-Amino-3,5-dimethyladamantane 1,3-Dimethyl-5-adamantanamine

Manufacturers

Actavis Pharma Company

CAS number

19982-08-2

UNII

W8O17SJF3T

State

solid

Affected organisms

Humans and other mammals

Indication of Memantine

For the treatment of moderate to severe dementia of the Alzheimer’s type.

Toxicity of Memantine

Side effects include pain, abnormal crying, leg pain, fever, increased apetite. Adverse drug reactions include: dizziness, confusion, headache, hallucinations, tiredness. Less common side effects include: vomiting, anxiety, hypertonia, cystitis, and increased libido. Doses of up to 400 mg have been tolerated.

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