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Price of Meprobamate
Meprobamate 200 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Meprobamate volume of distribution
What is Meprobamate
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Meprobamate is a controlled substance in the U.S.
Meprobamate mechanism of action
Meprobamate’s mechanism of action is not known. It has been shown in animal studies to have effects at multiple sites in the central nervous system, including the thalamus and limbic system. Meprobamate binds to GABA sub A /sub receptors which interrupt neuronal communication in the reticular formation and spinal cord, causing sedation and altered perception of pain.
Dosage forms of Meprobamate
282 Mep Tab
Merck Frosst Canada Cie, Merck Frosst Canada Co.
Humans and other mammals
Indication of Meprobamate
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety.
Toxicity of Meprobamate
Symptoms of overdose include coma, drowsiness, loss of muscle control, severely impaired breathing, shock, sluggishness, and unresponsiveness. Death has been reported with ingestion of as little as 12 g meprobamate and survival with as much as 40 g.
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