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2018 Price of Meropenem
Merrem 500 mg Solution Vial
vial
* price without discount in nearest pharmacy. Price may vary.
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Meropenem volume of distribution
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What is Meropenem
Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.
Meropenem mechanism of action
The bactericidal activity of meropenem results from the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding- protein (PBP) targets. Its strongest affinities are toward PBPs 2, 3 and 4 of iEscherichia coli/i and iPseudomonas aeruginosa/i; and PBPs 1, 2 and 4 of iStaphylococcus aureus/i.
Dosage forms of Meropenem
| Form | Route | Strength |
|---|---|---|
| Injection, powder, for solution | intravenous | 1 g/20mL |
| Injection, powder, for solution | intravenous | 1 g/30mL |
| Injection, powder, for solution | intravenous | 500 mg/10mL |
Prescription Generics
true
International Brands
Meropenem
Synonyms
(1R,5S,6S)-2-((3S,5S)-5-DIMETHYLAMINOCARBONYLPYRROLIDIN-3-ylthio)-6-((R)-1-hydroxyethyl)-1-methylcarbapen-2-em-3-carboxylic acid (4R,5S,6S)-3-{((3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl)thio}-6-((1R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid
Manufacturers
Gland Pharma Limited
CAS number
119478-56-7
UNII
FV9J3JU8B1
State
solid
Affected organisms
Enteric bacteria and other eubacteria
Indication of Meropenem
For use as single agent therapy for the treatment of the following infections when caused by susceptible isolates of the designated microorganisms: bcomplicated skin and skin structure infections/b due to iStaphylococcus aureus/i (b-lactamase and non-b-lactamase producing, methicillin-susceptible isolates only), iStreptococcus pyogenes/i, iStreptococcus agalactiae/i, viridans group streptococci, iEnterococcus faecalis/i (excluding vancomycin-resistant isolates), iPseudomonas aeruginosa/i, iEscherichia coli/i, iProteus mirabilis/i, iBacteroides fragilis/i and iPeptostreptococcus/i species; bcomplicated appendicitis and peritonitis/b caused by viridans group streptococci, iEscherichia coli/i, iKlebsiella pneumoniae/i, iPseudomonas aeruginosa/i, iBacteroides fragilis/i, iB. thetaiotaomicron/i, and iPeptostreptococcus/i species. Also for use in the treatment of bacterial meningitis caused by iStreptococcus pneumoniae/i, iHaemophilus influenzae/i (b-lactamase and non-b-lactamase-producing isolates), and iNeisseria meningitidis/i.
Toxicity of Meropenem
In mice and rats, large intravenous doses of meropenem (2200-4000 mg/kg) have been associated with ataxia, dyspnea, convulsions, and mortalities.
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