Save up -80% on Mesalazine
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2018 Price of Mesalazine
Pentasa 250 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Mesalazine volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Mesalazine
An anti-inflammatory agent, structurally related to the salicylates, which is active in inflammatory bowel disease. It is considered to be the active moiety of sulphasalazine. (From Martindale, The Extra Pharmacopoeia, 30th ed)
Mesalazine mechanism of action
Although the mechanism of action of mesalazine is not fully understood, it appears to be topical rather than systemic. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways, i.e., prostanoids, and through the lipoxygenase pathways, i.e., leukotrienes and hydroxyeicosatetraenoic acids, is increased in patients with chronic inflammatory bowel disease, and it is possible that mesalazine diminishes inflammation by blocking cyclooxygenase and inhibiting prostaglandin production in the colon.
Dosage forms of Mesalazine
|Capsule, extended release||oral||375 mg/1|
|Tablet (enteric-coated)||oral||400 mg|
Sanis Health Inc
Humans and other mammals
Indication of Mesalazine
For the treatment of active ulcerative proctitis.
Toxicity of Mesalazine
Oral, mouse: LD sub 50 /sub = 3370 mg/kg; Oral, rat: LD sub 50 /sub = 2800 mg/kg; Skin, rabbit: LD sub 50 /sub = gt;5 gm/kg. There have been no documented reports of serious toxicity in man resulting from massive overdosing with mesalamine. Under ordinary circumstances, mesalazine absorption from the colon is limited.
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