Save up -80% on Mesna

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
Pharmacists and Patients support.

2019 Price of Mesnex

$15.951 vial (10ml) 1g/10ml
price without discount in nearest pharmacy. Price may vary.

Claim your free Mesna discount card

We offer free Mesna coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Mesna every time. What are you waiting for? Claim your prescription drug card now!

Walgreens pharmacy
Walgreens pharmacy
CVS pharmacy
CVS pharmacy
Walmart pharmacy
Walmart pharmacy
Ride AID pharmacy
Ride AID pharmacy
CVS Target pharmacy
CVS Target pharmacy
Kroger pharmacy
Kroger pharmacy

Get your Prescription


It’s safe and free


Buy drugs in pharmacy

save money

Save money each time

Mesna volume of distribution

Vd = 0.652 0.242 L/Kg after intravenous administration of mesna.

RX Prescription
Ask Your therapeut before taking any drugs.

About RX24Drugs

2018 Statistics

discount card

Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Mesna

Mesna is a synthetic sulfhydryl (thiol) compound and is used for prophylaxis of Ifosfamide and cyclophosphamide induced hemorrhagic cystitis. (2)

Mesna mechanism of action

A metabolite called arolein is produced when ifosfamide and cyclophosphamide are metabolized. (1) This metabolite concentrates in the bladder and causes cell death via upregulation of reactive oxygen species (ROS), and activates inducible nitric oxide synthase (iNOS) which leads to production of nitric oxide (NO). (1) Both ROS and NO produce products which are detrimental to lipids, proteins and DNA strands. (1) Furthermore, ROS stimulate gene expression of pro-inflammatory cytokines such as TNF- AND IL-1 . (1) Acrolein may also lead to ulceration of the bladder urothelium. (1) Mesna protects against cyclophosphamide and ifosfamide induced hemorrhagic cystitis by binding to their toxic metabolites. (1) Mesna is metabolized to dimesna and excreted by the kidneys. (1) Glutathione dihydrogenase acts on the reabsorbed portion and produces free sulfhydryl groups. (1) These free sulfhydryl groups bind acrolein in the bladder, allowing effective excretion and prevention of toxic effects. (1) In addition, Mesna binds to and detoxifies a urotoxic ifosfamide metabolite called 4-hydroxy-ifosfamide.

Dosage forms of Mesna


Prescription Generics


International Brands



2-mercaptoethane sulfonate Na


Fresenius Kabi USA, LLC

CAS number






Affected organisms

Indication of Mesna

Mesna is a uroprotective agent and is used prophylactically to reduce ifosfamide and cyclophosphamide induced hemorrhagic cystitis. (2)

Toxicity of Mesna

The following adverse events were most common (10%) when mesna was administered with ifosfamide: nausea, vomiting, fatigue, fever, abdominal pain, constipation, diarrhea, leukopenia, anorexia, thrombocytopenia, anemia, granulocytopenia, asthenia, headache, alopecia, and somnolence. Hypersensitivity reactions and dermatologic toxicity may occur in patients taking mesna; therefore, if either reaction occurs, mesna should be discontinued and patient should be provided with supportive care.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Mesna on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

Get lower price on Mesna now!