Save up -80% on Metformin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Glucophage
|$4.11||60 tablets/500 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Metformin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Metformin every time. What are you waiting for? Claim your prescription drug card now!
Get your Prescription
It’s safe and free
Buy drugs in pharmacy
Save money each time
Metformin volume of distribution
654 L for metformin 850 mg administered as a single dose. The volume of distribution following IV administration is 63-276 L, likely due to less binding in the GI tract and/or different methods used to determine volume of distribution.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Metformin
Metformin is a biguanide antihyperglycemic agent used for treating non-insulin-dependent diabetes mellitus (NIDDM). It improves glycemic control by decreasing hepatic glucose production, decreasing glucose absorption and increasing insulin-mediated glucose uptake. Metformin may induce weight loss and is the drug of choice for obese NIDDM patients. Use of metformin is associated with modest weight loss. When used alone, metformin does not cause hypoglycemia; however, it may potentiate the hypoglycemic effects of sulfonylureas and insulin. Its main side effects are dyspepsia, nausea and diarrhea. Dose titration and/or use of smaller divided doses may decrease side effects. Metformin should be avoided in those with severely compromised renal function (creatinine clearance 30 ml/min), acute/decompensated heart failure, severe liver disease and for 48 hours after the use of iodinated contrast dyes due to the risk of lactic acidosis. Lower doses should be used in the elderly and those with decreased renal function. Metformin decreases fasting plasma glucose, postprandial blood glucose and glycosolated hemoglobin (HbA1c) levels, which are reflective of the last 8-10 weeks of glucose control. Metformin may also have a positive effect on lipid levels. In 2012, a combination tablet of linagliptin plus metformin hydrochloride was marketed under the name Jentadueto for use in patients when treatment with both linagliptin and metformin is appropriate.
Metformin mechanism of action
Metformin’s mechanisms of action differ from other classes of oral antihyperglycemic agents. Metformin decreases blood glucose levels by decreasing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization. These effects are mediated by the initial activation by metformin of AMP-activated protein kinase (AMPK), a liver enzyme that plays an important role in insulin signaling, whole body energy balance, and the metabolism of glucose and fats. Activation of AMPK is required for metformin’s inhibitory effect on the production of glucose by liver cells. Increased peripheral utilization of glucose may be due to improved insulin binding to insulin receptors. Metformin administration also increases AMPK activity in skeletal muscle. AMPK is known to cause GLUT4 deployment to the plasma membrane, resulting in insulin-independent glucose uptake. The rare side effect, lactic acidosis, is thought to be caused by decreased liver uptake of serum lactate, one of the substrates of gluconeogenesis. In those with healthy renal function, the slight excess is simply cleared. However, those with severe renal impairment may accumulate clinically significant serum lactic acid levels. Other conditions that may precipitate lactic acidosis include severe hepatic disease and acute/decompensated heart failure.
Dosage forms of Metformin
|Glumetza||1000mg||90 ER Tablet||$146.00|
|Glucophage XR||500mg||84 ER Tablet||$59.00|
|Metformin Hydrochloride Er||750mg||90 ER Tablet||$50.00|
|Kombiglyze XR||5/1000mg||84 Tablet||$198.00|
|Actoplus Met||15/850mg||56 Tablet||$121.00|
|Galvus Met||50/1000mg||120 Tablet||$181.00|
|Janumet XR||100/1000mg||84 Extended Release Tablet||$707.00|
|Janumet XR||100/1000mg||84 Extended Release Tablet||$707.00|
|Xigduo XR||10/1000mg||84 Tablet||$380.00|
Actavis Pharma Company
Humans and other mammals
Indication of Metformin
For use as an adjunct to diet and exercise in adult patients (18 years and older) with NIDDM. May also be used for the management of metabolic and reproductive abnormalities associated with polycystic ovary syndrome (PCOS). Jentadueto is for the treatment of patients when both linagliptin and metformin is appropriate.
Toxicity of Metformin
Acute oral toxicity (LD sub 50 /sub ): 350 mg/kg (Rabbit). It would be expected that adverse reactions of a more intense character including epigastric discomfort, nausea, and vomiting followed by diarrhea, drowsiness, weakness, dizziness, malaise and headache might be seen.
RX24 Drugs Disclaimer: before buying a Metformin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.
Get lower price on Metformin now!
What is Glucophage?
Glucophage is an oral hypoglycemic drug. The drug contains the active ingredient – metformin – a substance with a pronounced hypoglycemic effect, which develops only under the condition of hyperglycemia. In patients with normal plasma glucose levels, the drug does not have a hypoglycemic effect. In patients with hyperglycemia, the drug reduces the initial level of glucose in the blood plasma, as well as the level of glucose after a meal.
The mechanism of action of the drug is based on its ability to inhibit gluconeogenesis and glycogenolysis, increase insulin sensitivity, as well as reduce the absorption of glucose in the gastrointestinal tract. Thus, the drug helps to reduce glucose production in the liver, stimulates the capture and utilization of glucose by the muscles and reduces plasma glucose concentrations. In addition, metformin, regardless of the hypoglycemic effect, leads to an improvement in lipid metabolism, in particular, reduces the level of triglycerides, cholesterol and low-density lipoproteins.
After oral administration, the drug is well absorbed in the gastrointestinal tract, food intake reduces the absorption of metformin. The peak plasma concentration of metformin is observed 2.5 hours after oral administration of the drug Glucophage and 7 hours after taking the drug Glucophage XR. Absolute bioavailability when ingested reaches 50-60%. The drug is characterized by a low degree of communication with plasma proteins, metformin penetrates into red blood cells, while the plasma concentration of the drug is higher than the concentration in the blood. The drug is not metabolized in the body, excreted mainly by the kidneys, some of it is excreted by the intestines. The half-life is about 6.5 hours. In patients with impaired renal function, there is a decrease in clearance of metformin, which is proportional to the decrease in creatinine clearance.