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Price of Methohexital
Brevital sodium 2.5 gm vial
* price without discount in nearest pharmacy. Price may vary.
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Methohexital volume of distribution
What is Methohexital
An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia. (PubChem)
Methohexital mechanism of action
Methohexital binds at a distinct binding site associated with a Cl sup- /sup ionopore at the GABA subA /sub receptor, increasing the duration of time for which the Cl sup- /sup ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Dosage forms of Methohexital
|Injection, powder, lyophilized, for solution||intramuscular; intravenous; rectal||2.5 g/1|
|Injection, powder, lyophilized, for solution||intramuscular; intravenous; rectal||500 mg/1|
|Powder for solution||intravenous||500 mg|
A S Medication Solutions Llc
Humans and other mammals
Indication of Methohexital
Methohexital is indicated for use as an intravenous anaesthetic. It has also been commonly used to induce deep sedation.
Toxicity of Methohexital
The onset of toxicity following an overdose of intravenously administered methohexital will be within seconds of the infusion. If methohexital is administered rectally or is ingested, the onset of toxicity may be delayed. The manifestations of an ultrashort-acting barbiturate in overdose include central nervous system depression, respiratory depression, hypotension, loss of peripheral vascular resistance, and muscular hyperactivity ranging from twitching to convulsive-like movements. Other findings may include convulsions and allergic reactions. Following massive exposure to any barbiturate, pulmonary edema, circulatory collapse with loss of peripheral vascular tone, and cardiac arrest may occur.
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