Save up -80% on Methohexital

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Methohexital

Brevital sodium 2.5 gm vial



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Methohexital volume of distribution

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What is Methohexital

An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.

Methohexital mechanism of action

Methohexital binds at a distinct binding site associated with a Cl sup- /sup ionopore at the GABA subA /sub receptor, increasing the duration of time for which the Cl sup- /sup ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Dosage forms of Methohexital

Injection, powder, lyophilized, for solutionintramuscular; intravenous; rectal2.5 g/1
Injection, powder, lyophilized, for solutionintramuscular; intravenous; rectal500 mg/1
Powder for solutionintravenous500 mg
Prescription Generics


International Brands

Brevital Sodium


(+-)-5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid 5-Allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrione


A S Medication Solutions Llc

CAS number






Affected organisms

Humans and other mammals

Indication of Methohexital

Methohexital is indicated for use as an intravenous anaesthetic. It has also been commonly used to induce deep sedation.

Toxicity of Methohexital

The onset of toxicity following an overdose of intravenously administered methohexital will be within seconds of the infusion. If methohexital is administered rectally or is ingested, the onset of toxicity may be delayed. The manifestations of an ultrashort-acting barbiturate in overdose include central nervous system depression, respiratory depression, hypotension, loss of peripheral vascular resistance, and muscular hyperactivity ranging from twitching to convulsive-like movements. Other findings may include convulsions and allergic reactions. Following massive exposure to any barbiturate, pulmonary edema, circulatory collapse with loss of peripheral vascular tone, and cardiac arrest may occur.

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