Save up -80% on Methotrexate

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Rheumatrex

$22.0624 tablets/2.5mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Rheumatrex coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Methotrexate every time. What are you waiting for? Claim your prescription drug card now!

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Methotrexate volume of distribution

* 0.18 L/kg (initial volume of distribution (Vd)) * 0.4 – 0.8 L/kg (steady state Vd) Methotrexate competes with reduced folates for active transport across cell membranes by means of a single carrier-mediated active transport process. At serum concentrations greater than 100 micromolar, passive diffusion becomes a major pathway by which effective intracellular concentrations can be achieved. Methotrexate does not cross the blood-brain-barrier.

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2018 Statistics

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Clients Benefit 29%

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Total savings $4,735,080

What is Methotrexate

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Methotrexate mechanism of action

Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. The mechanism involved in its activity against rheumatoid arthritis is not known.

Dosage forms of Methotrexate

DrugDosageQuantityPrice
Methotrexate2.5mg100 Tablet$58.00
Rheumatrex2.5mg100 Tablet$115.00

Prescription Generics

true

International Brands

Apo-methotrexate

Synonyms

4-amino-10-methylfolic acid 4-amino-N(10)-Methylpteroylglutamic acid

Manufacturers

Apotex Inc

CAS number

59-05-2

UNII

YL5FZ2Y5U1

State

solid

Affected organisms

Humans and other mammals

Indication of Methotrexate

Methotrexate is indicated in the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole. In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of meningeal leukemia and is used in maintenance therapy in combination with other chemotherapeutic agents. Methotrexate is also indicated in the treatment of meningeal leukemia. Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T cell lymphoma), and lung cancer, particularly squamous cell and small cell types. Methotrexate is also used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkins lymphomas. Methotrexate is indicated in the symptomatic control of severe, recalcitrant, disabling psoriasis. Methotrexate is indicated in the management of selected adults with severe, active rheumatoid arthritis (ACR criteria), or children with active polyarticular-course juvenile rheumatoid arthritis.

Toxicity of Methotrexate

Symptoms of overdose include bone marrow suppression and gastrointestinal toxicity. LD sub50 /sub=43mg/kg(orally in rat).

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Methotrexate on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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