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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Methotrexate

Methotrexate 10 mg Tablet



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Methotrexate volume of distribution

* 0.18 L/kg (initial volume of distribution (Vd)) * 0.4 – 0.8 L/kg (steady state Vd) Methotrexate competes with reduced folates for active transport across cell membranes by means of a single carrier-mediated active transport process. At serum concentrations greater than 100 micromolar, passive diffusion becomes a major pathway by which effective intracellular concentrations can be achieved. Methotrexate does not cross the blood-brain-barrier.

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What is Methotrexate

An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.

Methotrexate mechanism of action

Methotrexate anti-tumor activity is a result of the inhibition of folic acid reductase, leading to inhibition of DNA synthesis and inhibition of cellular replication. The mechanism involved in its activity against rheumatoid arthritis is not known.

Dosage forms of Methotrexate

Injectionintra-arterial; intramuscular; intrathecal; intravenous25 mg/mL
Injection, powder, lyophilized, for solutionintra-arterial; intramuscular; intrathecal; intravenous1 g/1
Injection, solutionintra-arterial; intramuscular; intrathecal; intravenous1 g/40mL
Prescription Generics


International Brands



4-amino-10-methylfolic acid 4-amino-N(10)-Methylpteroylglutamic acid


Apotex Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Methotrexate

Methotrexate is indicated in the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole. In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of meningeal leukemia and is used in maintenance therapy in combination with other chemotherapeutic agents. Methotrexate is also indicated in the treatment of meningeal leukemia. Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T cell lymphoma), and lung cancer, particularly squamous cell and small cell types. Methotrexate is also used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkins lymphomas. Methotrexate is indicated in the symptomatic control of severe, recalcitrant, disabling psoriasis. Methotrexate is indicated in the management of selected adults with severe, active rheumatoid arthritis (ACR criteria), or children with active polyarticular-course juvenile rheumatoid arthritis.

Toxicity of Methotrexate

Symptoms of overdose include bone marrow suppression and gastrointestinal toxicity. LD sub50 /sub=43mg/kg(orally in rat).

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