Save up -80% on Methsuximide

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Methsuximide

Celontin 300 mg Capsule

$1.1

capsule

* price without discount in nearest pharmacy. Price may vary.

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Methsuximide volume of distribution

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What is Methsuximide

Mesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin.[Wikipedia]

Methsuximide mechanism of action

Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the “low-voltage activated (LVA)” group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Dosage forms of Methsuximide

FormRouteStrength
Capsuleoral300 mg/1
Capsuleoral300 mg
Prescription Generics

false

International Brands

Celontin

Synonyms

(RS)-1,3-Dimethyl-3-phenyl-2,5-pyrrolidindion 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine

Manufacturers

Parke Davis Div Of Pfizer Inc

CAS number

77-41-8

UNII

0G76K8X6C0

State

solid

Affected organisms

Humans and other mammals

Indication of Methsuximide

For the control of absence (petit mal) seizures that are refractory to other drugs.

Toxicity of Methsuximide

Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression. Levels greater than 40 -#181;g/mL have caused toxicity and coma has been seen at levels of 150 -#181;g/mL.

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