Save up -80% on Methsuximide
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2018 Price of Methsuximide
Celontin 300 mg Capsule
* price without discount in nearest pharmacy. Price may vary.
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Methsuximide volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Methsuximide
Mesuximide (or methsuximide) is an anticonvulsant medication. It is sold by Pfizer under the name Petinutin.[Wikipedia]
Methsuximide mechanism of action
Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the “low-voltage activated (LVA)” group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Dosage forms of Methsuximide
Parke Davis Div Of Pfizer Inc
Humans and other mammals
Indication of Methsuximide
For the control of absence (petit mal) seizures that are refractory to other drugs.
Toxicity of Methsuximide
Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression. Levels greater than 40 -#181;g/mL have caused toxicity and coma has been seen at levels of 150 -#181;g/mL.
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