Save up -80% on Methyldopa
Note: this is a drug discount program, not an insurance plan.
2018 Price of Methyldopa
Apo-Methyldopa 125 mg Tablet
* price without discount in nearest pharmacy. Price may vary.
We offer free Methyldopa coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Methyldopa every time. What are you waiting for? Claim your prescription drug card now!
Methyldopa volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Methyldopa mechanism of action
Although the mechanism of action has yet to be conclusively demonstrated, the resultant hypotensive effect is most likely due to the drug’s action on the CNS. Methyldopa is converted into the metabolite, alpha-methylnorepinephrine, in the CNS, where it stimulates the central inhibitory alpha-adrenergic receptors, leading to a reduction in sympathetic tone, total peripheral resistance, and blood pressure. Reduction in plasma renin activity, as well as the inhibition of both central and peripheral norepinephrine and serotonine production may also contribute to the drug’s antihypertensive effect, although this is not a major mechanism of action. This is done through the inhibition of the decarboxylation of dihydroxyphenylalanine (dopa)the precursor of norepinephrineand of 5-hydroxytryptophan (5-HTP)the precursor of serotoninin the CNS and in most peripheral tissues.
Dosage forms of Methyldopa
Aldomet Ester HCl Inj
Merck Frosst Canada Cie, Merck Frosst Canada Co.
Humans and other mammals
Toxicity of Methyldopa
The oral LD sub 50 /sub of methyldopa is greater than 1.5 g/kg in both the mouse and the rat. Symptoms of overdose include bloating, constipation, diarrhea, dizziness, extreme drowsiness, gas, light-headedness, nausea, severely low blood pressure, slow heartbeat, vomiting, and weakness.
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