Save up -80% on Methyldopa
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Aldomet
|$11.1||60 tablets/250 mg|
|price without discount in nearest pharmacy. Price may vary.|
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Methyldopa volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Methyldopa
An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
Methyldopa mechanism of action
Although the mechanism of action has yet to be conclusively demonstrated, the resultant hypotensive effect is most likely due to the drug’s action on the CNS. Methyldopa is converted into the metabolite, alpha-methylnorepinephrine, in the CNS, where it stimulates the central inhibitory alpha-adrenergic receptors, leading to a reduction in sympathetic tone, total peripheral resistance, and blood pressure. Reduction in plasma renin activity, as well as the inhibition of both central and peripheral norepinephrine and serotonine production may also contribute to the drug’s antihypertensive effect, although this is not a major mechanism of action. This is done through the inhibition of the decarboxylation of dihydroxyphenylalanine (dopa)the precursor of norepinephrineand of 5-hydroxytryptophan (5-HTP)the precursor of serotoninin the CNS and in most peripheral tissues.
Dosage forms of Methyldopa
Aldomet Ester HCl Inj
Merck Frosst Canada Cie, Merck Frosst Canada Co.
Humans and other mammals
Indication of Methyldopa
For use in the treatment of hypertension.
Toxicity of Methyldopa
The oral LD sub 50 /sub of methyldopa is greater than 1.5 g/kg in both the mouse and the rat. Symptoms of overdose include bloating, constipation, diarrhea, dizziness, extreme drowsiness, gas, light-headedness, nausea, severely low blood pressure, slow heartbeat, vomiting, and weakness.
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