Save up -80% on Methyldopa

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Methyldopa

Apo-Methyldopa 125 mg Tablet

$0.1

tablet

* price without discount in nearest pharmacy. Price may vary.

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Methyldopa volume of distribution

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What is Methyldopa

An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.

Methyldopa mechanism of action

Although the mechanism of action has yet to be conclusively demonstrated, the resultant hypotensive effect is most likely due to the drug’s action on the CNS. Methyldopa is converted into the metabolite, alpha-methylnorepinephrine, in the CNS, where it stimulates the central inhibitory alpha-adrenergic receptors, leading to a reduction in sympathetic tone, total peripheral resistance, and blood pressure. Reduction in plasma renin activity, as well as the inhibition of both central and peripheral norepinephrine and serotonine production may also contribute to the drug’s antihypertensive effect, although this is not a major mechanism of action. This is done through the inhibition of the decarboxylation of dihydroxyphenylalanine (dopa)the precursor of norepinephrineand of 5-hydroxytryptophan (5-HTP)the precursor of serotoninin the CNS and in most peripheral tissues.

Dosage forms of Methyldopa

FormRouteStrength
Liquidintravenous250 mg
Tabletoral125 mg
Tabletoral250 mg
Prescription Generics

false

International Brands

Aldomet Ester HCl Inj

Synonyms

(S)-(-)-alpha-Methyldopa 3-Hydroxy-alpha-methyl-L-tyrosine

Manufacturers

Merck Frosst Canada Cie, Merck Frosst Canada Co.

CAS number

555-30-6

UNII

M4R0H12F6M

State

solid

Affected organisms

Humans and other mammals

Indication of Methyldopa

For use in the treatment of hypertension.

Toxicity of Methyldopa

The oral LD sub 50 /sub of methyldopa is greater than 1.5 g/kg in both the mouse and the rat. Symptoms of overdose include bloating, constipation, diarrhea, dizziness, extreme drowsiness, gas, light-headedness, nausea, severely low blood pressure, slow heartbeat, vomiting, and weakness.

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