Save up -80% on Methyldopa

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Aldomet

$11.160 tablets/250 mg
Price with discount in nearest pharmacy. Price may vary.

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Methyldopa volume of distribution

The apparent volume of distribution in the central compartment is about 0.23L/kg (range 0.19 to 0.32L/kg), and the total volume of distribution (calculated as Vdarea) is about 0.60L/kg (range 0.41 to 0.72L/kg) in healthy volunteers. Acid-labile conjugates are formed after oral administration. These acid-labile conjugates, in particular the O-sulphate, are probably formed in the intestinal cells, since they are detected in very small amounts after intravenous administration.

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2018 Statistics

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Discount Cards 16,000+


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Total savings $4,735,080

What is Methyldopa

An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.

Methyldopa mechanism of action

Although the mechanism of action has yet to be conclusively demonstrated, the resultant hypotensive effect is most likely due to the drug’s action on the CNS. Methyldopa is converted into the metabolite, alpha-methylnorepinephrine, in the CNS, where it stimulates the central inhibitory alpha-adrenergic receptors, leading to a reduction in sympathetic tone, total peripheral resistance, and blood pressure. Reduction in plasma renin activity, as well as the inhibition of both central and peripheral norepinephrine and serotonine production may also contribute to the drug’s antihypertensive effect, although this is not a major mechanism of action. This is done through the inhibition of the decarboxylation of dihydroxyphenylalanine (dopa)the precursor of norepinephrineand of 5-hydroxytryptophan (5-HTP)the precursor of serotoninin the CNS and in most peripheral tissues.

Dosage forms of Methyldopa

Liquidintravenous250 mg
Tabletoral125 mg
Tabletoral250 mg

Prescription Generics


International Brands

Aldomet Ester HCl Inj


(S)-(-)-alpha-Methyldopa 3-Hydroxy-alpha-methyl-L-tyrosine


Merck Frosst Canada Cie, Merck Frosst Canada Co.

CAS number






Affected organisms

Humans and other mammals

Indication of Methyldopa

For use in the treatment of hypertension.

Toxicity of Methyldopa

The oral LD sub 50 /sub of methyldopa is greater than 1.5 g/kg in both the mouse and the rat. Symptoms of overdose include bloating, constipation, diarrhea, dizziness, extreme drowsiness, gas, light-headedness, nausea, severely low blood pressure, slow heartbeat, vomiting, and weakness.

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