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Price of Methylphenidate
Methylin ER 10 mg
* price without discount in nearest pharmacy. Price may vary.
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Methylphenidate volume of distribution
d-methylphenidate = 2.65 L/kg;
l-methylphenidate = 1.80 L/kg;
What is Methylphenidate
A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine. (PubChem)
Methylphenidate mechanism of action
Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal system and the cerebral cortex and causes increased sympathomimetic activity in the central nervous system. Alteration of serotonergic pathways via changes in dopamine transport may result.
Dosage forms of Methylphenidate
|Capsule, extended release||oral||15 mg/1|
|Capsule (extended release)||oral||10 mg|
|Capsule (extended release)||oral||15 mg|
alpha-Phenyl-2-piperidineacetic acid methyl ester
Humans and other mammals
Indication of Methylphenidate
For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Toxicity of Methylphenidate
Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD sub50 /sub=190mg/kg (orally in mice)
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