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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Methylphenidate

Methylin ER 10 mg

$1.0

tab

* price without discount in nearest pharmacy. Price may vary.

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Methylphenidate volume of distribution

d-methylphenidate = 2.65 L/kg; l-methylphenidate = 1.80 L/kg;

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What is Methylphenidate

A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.

Methylphenidate mechanism of action

Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal system and the cerebral cortex and causes increased sympathomimetic activity in the central nervous system. Alteration of serotonergic pathways via changes in dopamine transport may result.

Dosage forms of Methylphenidate

FormRouteStrength
Capsule, extended releaseoral15 mg/1
Capsule (extended release)oral10 mg
Capsule (extended release)oral15 mg
Prescription Generics

true

International Brands

Apo-methylphenidate

Synonyms

alpha-Phenyl-2-piperidineacetic acid methyl ester Daytrana

Manufacturers

Apotex Inc

CAS number

113-45-1

UNII

207ZZ9QZ49

State

solid

Affected organisms

Humans and other mammals

Indication of Methylphenidate

For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.

Toxicity of Methylphenidate

Symptoms of overdose include vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (may be followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, hyperpyrexia, tachycardia, palpitations, cardiac arrhythmias, hypertension, mydriasis, and dryness of mucous membranes. LD sub50 /sub=190mg/kg (orally in mice)

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