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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Metoclopramide

Metoclopramide Hydrochloride 5 mg/ml

$1.39

ml

* price without discount in nearest pharmacy. Price may vary.

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Metoclopramide volume of distribution

* 4.40.65 L/kg

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What is Metoclopramide

A dopamine D2 antagonist that is used as an antiemetic.

Metoclopramide mechanism of action

Metoclopramide inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic response of the gastrointestinal smooth muscle. It accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum. Simultaneously, this action is accompanied by relaxation of the upper small intestine, resulting in an improved coordination between the body and antrum of the stomach and the upper small intestine. Metoclopramide also decreases reflux into the esophagus by increasing the resting pressure of the lower esophageal sphincter and improves acid clearance from the esophagus by increasing amplitude of esophageal peristaltic contractions. Metoclopramide’s dopamine antagonist action raises the threshold of activity in the chemoreceptor trigger zone and decreases the input from afferent visceral nerves. Studies have also shown that high doses of metoclopramide can antagonize 5-hydroxytryptamine (5-HT) receptors in the peripheral nervous system in animals.

Dosage forms of Metoclopramide

FormRouteStrength
Tabletoral10 mg
Tabletoral5 mg
Liquidoral1 mg
Prescription Generics

true

International Brands

Apo-metoclop Tab 10mg

Synonyms

2-Methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide 2-methoxy-5-chloroprocainamide

Manufacturers

Apotex Inc

CAS number

364-62-5

UNII

L4YEB44I46

State

solid

Affected organisms

Humans and other mammals

Indication of Metoclopramide

For the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.

Toxicity of Metoclopramide

Oral, mouse LD sub50 /sub: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.

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