Save up -80% on Metoclopramide
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2018 Price of Metoclopramide
Metoclopramide Hydrochloride 5 mg/ml
* price without discount in nearest pharmacy. Price may vary.
We offer free Metoclopramide coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Metoclopramide every time. What are you waiting for? Claim your prescription drug card now!
Metoclopramide volume of distribution
* 4.40.65 L/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Metoclopramide mechanism of action
Metoclopramide inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic response of the gastrointestinal smooth muscle. It accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum. Simultaneously, this action is accompanied by relaxation of the upper small intestine, resulting in an improved coordination between the body and antrum of the stomach and the upper small intestine. Metoclopramide also decreases reflux into the esophagus by increasing the resting pressure of the lower esophageal sphincter and improves acid clearance from the esophagus by increasing amplitude of esophageal peristaltic contractions. Metoclopramide’s dopamine antagonist action raises the threshold of activity in the chemoreceptor trigger zone and decreases the input from afferent visceral nerves. Studies have also shown that high doses of metoclopramide can antagonize 5-hydroxytryptamine (5-HT) receptors in the peripheral nervous system in animals.
Dosage forms of Metoclopramide
Apo-metoclop Tab 10mg
Humans and other mammals
Toxicity of Metoclopramide
Oral, mouse LD sub50 /sub: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions.
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