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Price of Metolazone
Metolazone 2.5 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Metolazone volume of distribution
What is Metolazone
A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. (PubChem)
Metolazone mechanism of action
The actions of metolazone result from interference with the renal tubular mechanism of electrolyte reabsorption. Metolazone acts primarily to inhibit sodium reabsorption at the cortical diluting site and to a lesser extent in the proximal convoluted tubule. Sodium and chloride ions are excreted in approximately equivalent amounts. The increased delivery of sodium to the distal tubular exchange site results in increased potassium excretion. Metolazone does not inhibit carbonic anhydrase. The antihypertensive mechanism of action of metolazone is not fully understood but is presumed to be related to its saluretic and diuretic properties.
Dosage forms of Metolazone
Upstate Pharma, LLC
Humans and other mammals
Indication of Metolazone
For the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class.
Toxicity of Metolazone
Symptoms of overdose include difficulty breathing, dizziness, dizziness on standing up, drowsiness, fainting, irritation of the stomach and intestines, and lethargy leading to coma.
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