Save up -80% on Metoprolol

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Lopressor

$7.0760 tablets/25 mg
Price with discount in nearest pharmacy. Price may vary.

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Metoprolol volume of distribution

Volume of distribution of 5.6 L/kg.

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What is Metoprolol

Metoprolol is a cardioselective 1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the i para /i position of the benzene ring. The 1-selectivity of these agents is thought to be due in part to the large substituents in the i para /i position. At low doses, metoprolol selectively blocks cardiac 1-adrenergic receptors with little activity against 2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with higher doses. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for -adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture.

Metoprolol mechanism of action

Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.

Dosage forms of Metoprolol

Metoprolol Tartrate25mg100 Tablet$33.50
Metoprolol Tartrate50mg100 Tablet$35.50
Metoprolol Tartrate Sr100mg100 Sustained Release Tablet$53.00
Metoprolol Succinate12.5mg100 Extended ReleaseTablet$56.00
Metoprolol Succinate200mg90 Extended ReleaseTablet$97.00
Lopressor50mg100 Tablet$55.50
Lopressor100mg100 Tablet$70.00
Lopressor SR100mg100 Tablet SR$67.50
Lopressor SR200mg84 ER Tablet$78.00
Toprol XL25mg100 Extended ReleaseTablet$70.00
Toprol XL50mg100 Extended ReleaseTablet$75.00
Toprol XL100mg100 Extended ReleaseTablet$46.80

Prescription Generics


International Brands

Apo Metoprolol (type L) Tab 50mg


(RS)-Metoprolol 1-(isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol


Apotex Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Metoprolol

For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.

Toxicity of Metoprolol

LD sub 50 /sub =5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD sub 50 /sub =2090 mg/kg (orally in mice)

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