Save up -80% on Metoprolol
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Lopressor
|$7.07||60 tablets/25 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Metoprolol coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Metoprolol every time. What are you waiting for? Claim your prescription drug card now!
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Metoprolol volume of distribution
Volume of distribution of 5.6 L/kg.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Metoprolol
Metoprolol is a cardioselective 1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the i para /i position of the benzene ring. The 1-selectivity of these agents is thought to be due in part to the large substituents in the i para /i position. At low doses, metoprolol selectively blocks cardiac 1-adrenergic receptors with little activity against 2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with higher doses. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for -adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture.
Metoprolol mechanism of action
Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.
Dosage forms of Metoprolol
|Metoprolol Tartrate||25mg||100 Tablet||$33.50|
|Metoprolol Tartrate||50mg||100 Tablet||$35.50|
|Metoprolol Tartrate Sr||100mg||100 Sustained Release Tablet||$53.00|
|Metoprolol Succinate||12.5mg||100 Extended ReleaseTablet||$56.00|
|Metoprolol Succinate||200mg||90 Extended ReleaseTablet||$97.00|
|Lopressor SR||100mg||100 Tablet SR||$67.50|
|Lopressor SR||200mg||84 ER Tablet||$78.00|
|Toprol XL||25mg||100 Extended ReleaseTablet||$70.00|
|Toprol XL||50mg||100 Extended ReleaseTablet||$75.00|
|Toprol XL||100mg||100 Extended ReleaseTablet||$46.80|
Apo Metoprolol (type L) Tab 50mg
Humans and other mammals
Indication of Metoprolol
For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
Toxicity of Metoprolol
LD sub 50 /sub =5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD sub 50 /sub =2090 mg/kg (orally in mice)
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