Save up -80% on Metoprolol
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2018 Price of Metoprolol
Metoprolol Succinate 50 mg 24 Hour tablet
* price without discount in nearest pharmacy. Price may vary.
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Metoprolol volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Metoprolol
Metoprolol is a cardioselective 1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the i para /i position of the benzene ring. The 1-selectivity of these agents is thought to be due in part to the large substituents in the i para /i position. At low doses, metoprolol selectively blocks cardiac 1-adrenergic receptors with little activity against 2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with higher doses. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for -adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture.
Metoprolol mechanism of action
Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure.
Dosage forms of Metoprolol
|Tablet, film coated||oral|
Apo Metoprolol (type L) Tab 50mg
Humans and other mammals
Indication of Metoprolol
For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
Toxicity of Metoprolol
LD sub 50 /sub =5500 mg/kg (orally in rats), toxic effects include bradycardia, hypotension, bronchospasm, and cardiac failure. LD sub 50 /sub =2090 mg/kg (orally in mice)
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