Save up -80% on Metronidazole
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Flagyl
|$7.80||14 tablets/500 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Metronidazole coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Metronidazole every time. What are you waiting for? Claim your prescription drug card now!
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Metronidazole volume of distribution
Volume of distribution: 0.51 to 1.1L/kg (adults)
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Metronidazole
A nitroimidazole used to treat amebiasis; vaginitis; trichomonas infections; giardiasis; anaerobic bacteria; and treponemal infections. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).
Metronidazole mechanism of action
Metronidazole is a prodrug. Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then covalently binds to DNA, disrupt its helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death.
Dosage forms of Metronidazole
|Noritate Cream||1%||45g Cream||$55.00|
|Nidagel||0.75%||70g Vaginal gel||$46.00|
|Flagystatin Suppository||500mg/100000units||10 Vaginal suppository||$59.50|
|Flagystatin Cream||500mg/100000units||55g Vaginal cream||$59.50|
Bacteria and protozoa
Indication of Metronidazole
For the treatment of anaerobic infections and mixed infections, surgical prophylaxis requiring anaerobic coverage, Clostridium difficile-associated diarrhea and colitis, Helicobacter pylori infection and duodenal ulcer disease, bacterial vaginosis, Giardia lamblia gastro-enteritis, amebiasis caused by Entamoeba histolytica, acne rosacea (topical treatment), and Trichomonas infections.
Toxicity of Metronidazole
LD50=500 mg/kg/day (orally in rat). Adverse effects include reversible peripheral neuropathy with prolonged therapy, CNS toxicity, disulfiram effect with alcohol, dark red-brown urine, metallic taste, nausea, epigastric distress, dizziness, vertigo and paresthesias associated with high doses, and neutropenia (reversible and mild).
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