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2018 Price of Metyrapone
Metopirone 250 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Metyrapone volume of distribution
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What is Metyrapone
An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
Metyrapone mechanism of action
The pharmacological effect of Metopirone is to reduce cortisol and corticosterone production by inhibiting the 11-szlig;-hydroxylation reaction in the adrenal cortex. Removal of the strong inhibitory feedback mechanism exerted by cortisol results in an increase in adrenocorticotropic hormone (ACTH) production by the pituitary. With continued blockade of the enzymatic steps leading to production of cortisol and corticosterone, there is a marked increase in adrenocortical secretion of their immediate precursors, 11-desoxycortisol and desoxycorticosterone, which are weak suppressors of ACTH release, and a corresponding elevation of these steroids in the plasma and of their metabolites in the urine. These metabolites are readily determined by measuring urinary 17-hydroxycorticosteroids (17-OHCS) or 17-ketogenic steroids (17-KGS). Because of these actions, metopirone is used as a diagnostic test, with urinary 17-OHCS measured as an index of pituitary ACTH responsiveness. Metopirone may also suppress biosynthesis of aldosterone, resulting in a mild natriuresis.
Dosage forms of Metyrapone
|Capsule, gelatin coated||oral||250 mg/1|
Laboratoire HRA Pharma
Humans and other mammals
Indication of Metyrapone
Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function. Occasionally used in Cushing’s syndrome.
Toxicity of Metyrapone
Oral LD sub 50 /sub in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.
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