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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Metopirone

$181.329 capsules/250mg
price without discount in nearest pharmacy. Price may vary.

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Metyrapone volume of distribution

After administration of 4.5 g metyrapone (750 mg every 4 hours), an average of 5.3% of the dose was excreted in the urine in the form of metyrapone (9.2% free and 90.8% as glucuronide) and 38.5% in the form of metyrapol (8.1% free and 91.9% as glucuronide) within 72 hours after the first dose was given.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Metyrapone

An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.

Metyrapone mechanism of action

The pharmacological effect of Metopirone is to reduce cortisol and corticosterone production by inhibiting the 11-szlig;-hydroxylation reaction in the adrenal cortex. Removal of the strong inhibitory feedback mechanism exerted by cortisol results in an increase in adrenocorticotropic hormone (ACTH) production by the pituitary. With continued blockade of the enzymatic steps leading to production of cortisol and corticosterone, there is a marked increase in adrenocortical secretion of their immediate precursors, 11-desoxycortisol and desoxycorticosterone, which are weak suppressors of ACTH release, and a corresponding elevation of these steroids in the plasma and of their metabolites in the urine. These metabolites are readily determined by measuring urinary 17-hydroxycorticosteroids (17-OHCS) or 17-ketogenic steroids (17-KGS). Because of these actions, metopirone is used as a diagnostic test, with urinary 17-OHCS measured as an index of pituitary ACTH responsiveness. Metopirone may also suppress biosynthesis of aldosterone, resulting in a mild natriuresis.

Dosage forms of Metyrapone

FormRouteStrength
Capsule, gelatin coatedoral250 mg/1

Prescription Generics

false

International Brands

Metopirone

Synonyms

Metirapona Metopiron

Manufacturers

Laboratoire HRA Pharma

CAS number

54-36-4

UNII

ZS9KD92H6V

State

solid

Affected organisms

Humans and other mammals

Indication of Metyrapone

Used as a diagnostic drug for testing hypothalamic-pituitary ACTH function. Occasionally used in Cushing’s syndrome.

Toxicity of Metyrapone

Oral LD sub 50 /sub in rats is 521 mg/kg. One case has been recorded in which a 6-year-old girl died after two doses of Metopirone, 2 g. Symptoms of overdose include cardiac arrhythmias, hypotension, dehydration, anxiety, confusion, weakness, impairment of consciousness, nausea, vomiting, epigastric pain, and diarrhea.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Metyrapone on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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