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Price of Mexiletine
Mexiletine 150 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Mexiletine volume of distribution
* 5 to 7 L/lg
What is Mexiletine
Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. (PubChem)
Mexiletine mechanism of action
Mexiletine, like lidocaine, inhibits the inward sodium current required for the initiation and conduction of impulses, thus reducing the rate of rise of the action potential, Phase 0. It achieves this reduced sodium current by inhibiting sodium channels. Mexiletine decreases the effective refractory period (ERP) in Purkinje fibers in the heart. The decrease in ERP is of lesser magnitude than the decrease in action potential duration (APD), which results in an increase in the ERP/APD ratio. It does not significantly affect resting membrane potential or sinus node automaticity, left ventricular function, systolic arterial blood pressure, atrioventricular (AV) conduction velocity, or QRS or QT intervals
Dosage forms of Mexiletine
Altimed Pharma Inc.
Humans and other mammals
Indication of Mexiletine
For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.
Toxicity of Mexiletine
Symptoms of overdose include nausea, hypotension, sinus bradycardia, paresthesia, seizures, bundle branch block, AV heart block, asystole, ventricular tachyarrythmia, including ventricular fibrillation, cardiovascular collapse, and coma.
Disclaimer: before buying a Mexiletine on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.