Save up -80% on Micafungin
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2018 Price of Micafungin
Mycamine 50 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Micafungin volume of distribution
* 0.39 0.11 L/kg (adult patients with esophageal candidiasis)
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Micafungin
Micafungin is an antifungal drug. It belongs to the antifungal class of compounds known as echinocandins and exerts its effect by inhibiting the synthesis of 1,3-beta-D-glucan, an integral component of the fungal cell wall.
Micafungin mechanism of action
Micafungin inhibits the synthesis of beta-1,3-D-glucan, an essential component of fungal cell walls which is not present in mammalian cells. It does this by inhibiting beta-1,3-D-glucan synthase.
Dosage forms of Micafungin
|Injection, powder, lyophilized, for solution||intravenous||10 mg/mL|
|Injection, powder, lyophilized, for solution||intravenous||20 mg/mL|
|Powder for solution||intravenous||100 mg|
Astellas Pharma Canada Inc
Aspergillis, Candida and other fungi
Indication of Micafungin
For use in the treatment of candidemia, acute disseminated candidiasis, and certain other invasive iCandida /i infections, as well as esophageal candidiasis, and prophylaxis of iCandida /i infections in patients undergoing hematopoietic stem cell transplantation. Micafungin is also used as an alternative for the treatment of oropharyngeal candidiases and has been used with some success as primary or salvage therapy, alone or in combination with other antifungals, for the treatment of invasive aspergillosis.
Toxicity of Micafungin
Intravenous LD sub50 /sub in rats is 125mg/kg. In dogs it is 200mg/kg. No cases of overdosage have been reported. Repeated daily doses up to 8 mg/kg (maximum total dose of 896 mg) in adult patients have been administered in clinical trials with no reported dose-limiting toxicity. The minimum lethal dose is 125 mg/kg in rats, equivalent to 8.1 times the recommended human clinical dose for esophageal candidiasis based on body surface area comparisons.
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