Save up -80% on Midazolam
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Versed
|$4.08||2 vials (1ml) 5mg/ml|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Midazolam coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Midazolam every time. What are you waiting for? Claim your prescription drug card now!
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Midazolam volume of distribution
* 1.24 to 2.02 L/kg (pediatric patients (6 months to 16 years) receiving 0.15 mg/kg IV midazolam,) * 1 to 3.1 L/kg (intravenously administered, healthy adults) Female gender, old age, and obesity may increase the volume of distribution. Midazolam may also cross the placenta and has been detected in human milk and cerebrospinal fluid.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Midazolam
A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH. Midazolam is a schedule IV drug in the United States.
Midazolam mechanism of action
It is thought that the actions of benzodiazepines such as midazolam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which is one of the major inhibitory neurotransmitters in the brain. Benzodiazepines increase the activity of GABA, thereby producing a calming effect, relaxing skeletal muscles, and inducing sleep. Benzodiazepines bind to the benzodiazepine site on GABA-A receptors, which potentiates the effects of GABA by increasing the frequency of chloride channel opening.
Dosage forms of Midazolam
|Liquid||intramuscular; intravenous||1 mg|
|Liquid||intramuscular; intravenous||5 mg|
|Oromucosal solution||Oromucosal use||10 mg|
Apo-midazolam Injectable 1 mg/ml
Humans and other mammals
Indication of Midazolam
The midazolam injection is indicated for preoperative sedation/anziolysis/amnesia. It is also an agent for sedation/anziolysis/amnesia prior to or during diagnostic, therapeutic, or endoscopic procedures. Midazolam can also be given intravenously for induction of general anaesthesia.
Toxicity of Midazolam
LD sub50 /sub=825 mg/kg (Orally in rats). Signs of overdose include sedation, somnolence, confusion, impaired coordination, diminished reflexes, coma, and deleterious effects on vital signs.
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