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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Versed

$4.082 vials (1ml) 5mg/ml
price without discount in nearest pharmacy. Price may vary.

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Midazolam volume of distribution

* 1.24 to 2.02 L/kg (pediatric patients (6 months to 16 years) receiving 0.15 mg/kg IV midazolam,) * 1 to 3.1 L/kg (intravenously administered, healthy adults) Female gender, old age, and obesity may increase the volume of distribution. Midazolam may also cross the placenta and has been detected in human milk and cerebrospinal fluid.

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Total savings $4,735,080

What is Midazolam

A short-acting hypnotic-sedative drug with anxiolytic and amnestic properties. It is used in dentistry, cardiac surgery, endoscopic procedures, as preanesthetic medication, and as an adjunct to local anesthesia. The short duration and cardiorespiratory stability makes it useful in poor-risk, elderly, and cardiac patients. It is water-soluble at pH less than 4 and lipid-soluble at physiological pH. Midazolam is a schedule IV drug in the United States.

Midazolam mechanism of action

It is thought that the actions of benzodiazepines such as midazolam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which is one of the major inhibitory neurotransmitters in the brain. Benzodiazepines increase the activity of GABA, thereby producing a calming effect, relaxing skeletal muscles, and inducing sleep. Benzodiazepines bind to the benzodiazepine site on GABA-A receptors, which potentiates the effects of GABA by increasing the frequency of chloride channel opening.

Dosage forms of Midazolam

FormRouteStrength
Liquidintramuscular; intravenous1 mg
Liquidintramuscular; intravenous5 mg
Oromucosal solutionOromucosal use10 mg

Prescription Generics

true

International Brands

Apo-midazolam Injectable 1 mg/ml

Synonyms

Buccolam Dormicum

Manufacturers

Apotex Inc

CAS number

59467-70-8

UNII

R60L0SM5BC

State

solid

Affected organisms

Humans and other mammals

Indication of Midazolam

The midazolam injection is indicated for preoperative sedation/anziolysis/amnesia. It is also an agent for sedation/anziolysis/amnesia prior to or during diagnostic, therapeutic, or endoscopic procedures. Midazolam can also be given intravenously for induction of general anaesthesia.

Toxicity of Midazolam

LD sub50 /sub=825 mg/kg (Orally in rats). Signs of overdose include sedation, somnolence, confusion, impaired coordination, diminished reflexes, coma, and deleterious effects on vital signs.

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